Glucose Metabolism and Sleep in People With Family History of Type 2 Diabetes.
The use of sugar and starch-like foods for energy (carbohydrate metabolism) changes when people sleep. However, it is still not known if differences in the amount of nighttime sleep have an effect on the carbohydrate metabolism of people who have a relative with type 2 diabetes (parent, sibling, or grandparent). This study is being done to test the hypothesis that individual differences in habitual sleep duration may be related to differences in the carbohydrate metabolism of people who have a history of type 2 diabetes in their family.
Type 2 Diabetes
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Sleep, Energy Metabolism and Diabetes Risk.|
- Total body insulin sensitivity [ Time Frame: at the end of a 4-hour hyperinsulinemic clamp ] [ Designated as safety issue: No ]
- First and second phase insulin secretion [ Time Frame: during a 3-hour hyperglycemic clamp ] [ Designated as safety issue: No ]
- Endogenous glucose production [ Time Frame: before and during a 4-hour hyperinsulinemic clamp ] [ Designated as safety issue: No ]
- Glycerol turnover and free fatty acid concentration [ Time Frame: before and during a 4-hour hyperinsulinemic clamp ] [ Designated as safety issue: No ]
|Study Start Date:||July 2008|
|Study Completion Date:||March 2012|
|Primary Completion Date:||March 2012 (Final data collection date for primary outcome measure)|
Habitual sleep duration of less than 6 hours per night on most days of the week and total sleep of less than 43 hours per week.
Habitual sleep duration between 7 and 8.5 hours per night on most days of the week and total sleep of at least 53 hours per week.
On two consecutive inpatient days, the participants in this study will undergo two different tests. The first test will determine how much insulin can their body produce in response to an intravenous glucose infusion over a period of several hours. The second test will determine how effective is the action of the sugar-processing hormone, insulin, in their body when it is infused intravenously together with glucose over a period of several hours.
|United States, Illinois|
|University of Chicago|
|Chicago, Illinois, United States, 60637|
|Principal Investigator:||Plamen D Penev, MD, PhD||University of Chicago|