Assess Vitamin D Levels in Those With & Without Thyroid Cancer
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Purpose
The purpose of this study is to evaluate Vitamin D levels in thyroid cancer patients with active disease compared with thyroid cancer patients in remission and patients with thyroid nodules.
| Condition |
|---|
|
Thyroid Cancer |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Prospective |
| Official Title: | The Relationship Between Vitamin D and Thyroid Cancer |
- Number of Persons That Are Vitamin D Deficient in the Thyroid Nodule, Thyroid Cancer in Remission, and the Active Thyroid Cancer Groups. [ Time Frame: Within 12 months of enrollment in thyroid cancer collaborative registry (TCCR) database ] [ Designated as safety issue: No ]We evaluated serum calcium,creatinine,albumin,and 25-hydroxyvitaminD(25-OH-D)in 42 thyroid nodule, 45 thyroid cancer in remission, & 24 active thyroid cancer patients. We also determined the number and percent of participants in each group that had vitamin D deficiency, defined as 25-OH-D < 30 ng/ml.
Biospecimen Retention: Samples With DNA
Whole blood.
| Enrollment: | 111 |
| Study Start Date: | March 2008 |
| Study Completion Date: | June 2009 |
| Primary Completion Date: | March 2009 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
Thyroid Cancer in Remission Group
Thyroid Cancer-Remission Group & use of Vitamin D
|
|
Thyroid Cancer with Active Disease Group
Thyroid Cancer-Active Group & use of Vitamin D
|
|
Thyroid nodule group (no cancer) & Vit D
Thyroid nodule group without cancer and use of Vitamin D
|
Detailed Description:
Thyroid cancer is the most common endocrine related malignancy, increasing in incidence in recent years. There are relatively few, well known factors, both genetic and environmental, which predispose to the development of thyroid cancer. Vitamin D deficiency has been associated with other cancers, but the association between vitamin D and thyroid cancer is unknown. We plan to do a case control, pilot study to evaluate the relationship between vitamin D levels and thyroid nodules, thyroid cancer in remission, and active thyroid cancer.
Eligibility| Ages Eligible for Study: | 19 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
The Thyroid Tumor and Cancer Collaborative Registry (TCCR) is a thyroid cancer and thyroid nodule database at the University of Nebraska Medical Center. The database serves as a registry and biospecimen bank for those who wish to participate in multidisciplinary research. The database will be accessed to query for individuals with a diagnosis of thyroid cancer, both active disease and in remission, as well as a diagnosis of thyroid nodules. Those meeting eligibility requirements will then have their registry information and stored biospecimens accessed for testing and review.
Inclusion Criteria:
- Cases: History of Papillary, Follicular, Follicular Variant of Papillary, or Hurthle cell thyroid cancer (both active disease and in remission).
- Controls: Individuals with a thyroid nodule, matched to cases for age, BMI, season of vitamin D measurement.
- Participating in University of Nebraska Medical Center Thyroid Tumor and Cancer Collaborative Registry database.
Exclusion Criteria:
- Pregnant or breast feeding women
- Medullary thyroid cancer
- Anaplastic thyroid cancer
Contacts and Locations| United States, Nebraska | |
| University of Nebraska Medical Center | |
| Omaha, Nebraska, United States, 68198 | |
| Principal Investigator: | Nathan W Laney, MD | University of Nebraska Medical Center, Department of Internal Medicine, Section of DEM |
More Information
Publications:
| Responsible Party: | Whitney Goldner, MD, University of Nebraska Medical Center |
| ClinicalTrials.gov Identifier: | NCT00719615 History of Changes |
| Other Study ID Numbers: | 136-08-EP |
| Study First Received: | July 17, 2008 |
| Results First Received: | January 27, 2010 |
| Last Updated: | March 15, 2010 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by University of Nebraska:
|
Thyroid Cancer Thyroid Nodules Vitamin D |
Additional relevant MeSH terms:
|
Thyroid Neoplasms Thyroid Diseases Endocrine Gland Neoplasms Neoplasms by Site Neoplasms Head and Neck Neoplasms Endocrine System Diseases Vitamin D |
Ergocalciferols Vitamins Bone Density Conservation Agents Physiological Effects of Drugs Pharmacologic Actions Micronutrients Growth Substances |
ClinicalTrials.gov processed this record on May 22, 2013