S-100B as Pre-Head CT Scan Screening Test After Mild Traumatic Brain Injury
The purpose of the study is to determine if a specific blood protein, S-100B, can help predict who will have a traumatic abnormality on head CT scan after a concussion. We will compare the levels of this protein in the subject's blood to the initial head CT scan and to how the subject is feeling one month after injury. We hope that the information we collect in this trial will help us determine who needs a head CT scan after a concussion and who may be more likely to have trouble recovering from a concussion.
Traumatic Brain Injury
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Accuracy of S-100B as Pre-Head CT Scan Screening Test After Mild Traumatic Brain Injury|
- Head CT scan [ Time Frame: At time of injury in ED ] [ Designated as safety issue: No ]
- Post concussive symptoms [ Time Frame: One month after injury ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
|Study Start Date:||September 2008|
|Study Completion Date:||September 2010|
|Primary Completion Date:||September 2010 (Final data collection date for primary outcome measure)|
Patients presenting to any of the AHCC/ERNES Emergency Departments with head trauma.
Patients presenting to the Univ of Rochester Medical Center/Strong Memorial Hospital Outpatient Laboratory for routine blood draw.
The primary objective of this study is to determine the ability of a serum S-100B to predict traumatic abnormalities on brain CT scan after mild traumatic brain injury (mild TBI). The secondary objective is to determine the relationship between initial S-100B levels and cognitive outcome at one month.
|United States, New York|
|Albany Medical College|
|Albany, New York, United States, 12208|
|Erie County Medical Center|
|Buffalo, New York, United States, 14215|
|Cooperstown, New York, United States, 13326|
|University of Rochester Medical Center|
|Rochester, New York, United States, 14642|
|SUNY Upstate Medical Center at Syracuse|
|Syracuse, New York, United States, 13210|
|United States, Pennsylvania|
|Sayre, Pennsylvania, United States, 18840|
|Principal Investigator:||Jeffrey J Bazarian, MD, MPH||University of Rochester|