Effects of Oxygen on Lung Tissue During Anesthesia
Recruitment status was Active, not recruiting
Collect exhaled breath condensates from patients scheduled for a routine surgical procedure before, during, and after surgery for measurements of IsoFs
Draw blood from patients scheduled for a routine surgical procedure before, during, and after surgery for measurements of serum thrombomodulin.
Lung Injury, Acute
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Effects of Oxygen on Lung Tissue During Anesthesia|
|Study Start Date:||June 2008|
|Estimated Study Completion Date:||August 2009|
|Estimated Primary Completion Date:||June 2009 (Final data collection date for primary outcome measure)|
High concentrations of oxygen are routinely administered to patients undergoing routine surgical procedures even though it is highly likely, at least in patients with normal lung function, that this is unnecessary and in fact may be doing unnecessary harm. Therefore, we plan to assess whether there is any evidence of lung injury during surgery resulted from administration of high concentrations of oxygen by measuring Isofurans (IsoFs) in exhaled breath condensate. In our studies in mice that were exposed to high concentrations of oxygen we also found that circulating levels of thrombomodulin were increased. Thrombomodulin is present in endothelial cells and upon injury they release thrombomodulin into the circulation. Endothelial cell injury is known to occur in hyperoxic-induced lung injury. Therefore, in addition to measuring IsoFs in exhaled breath condensate we will also measure plasma concentrations of thrombomodulin as an indicator of endothelial injury.
|United States, Tennessee|
|Vanderbilt University Medical Center|
|Nashville, Tennessee, United States, 37212|
|Principal Investigator:||John A Barwise, M.D.||Vanderbilt University|