Feasibility Study of the Execution of an Efficacy Trial in the Nursing Home Setting

This study has been withdrawn prior to enrollment.
(The study was terminated due to the inability to enroll subjects. No subjects were or ever will be enrolled into this study.)
Sponsor:
Information provided by:
Healthpoint
ClinicalTrials.gov Identifier:
NCT00714519
First received: July 10, 2008
Last updated: August 29, 2013
Last verified: August 2013
  Purpose

This study will assess if a clinical trial regarding healing of partial thickness wounds can be executed in nursing homes.


Condition Intervention Phase
Partial Thickness Wounds
Drug: Xenaderm® Ointment
Drug: Placebo Comparator
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Double Blind (Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Phase II Feasibility Study of Xenaderm® Ointment Exploring Design Issues for Phase III Efficacy in Partial-Thickness Wounds

Resource links provided by NLM:


Further study details as provided by Healthpoint:

Primary Outcome Measures:
  • Complete Wound Closure [ Time Frame: 21 days ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Adverse Events [ Time Frame: 21 days ] [ Designated as safety issue: Yes ]

Enrollment: 0
Study Start Date: July 2008
Study Completion Date: October 2008
Primary Completion Date: October 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1 Drug: Xenaderm® Ointment
Topical, BID or as needed
Other Name: Placebo Comparator
Placebo Comparator: 2 Drug: Placebo Comparator
Topical, BID or as needed
Other Name: Xenaderm® Ointment

Detailed Description:

This study will test the efficacy of Xenaderm® vs. vehicle on the healing of partial thickness wounds caused by pressure, moisture and friction.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Provide written informed consent, which consists of reading, signing and dating the informed consent document after the Investigator, sub-Investigator or other designated study staff member has explained the study procedures, risks, and contact information. If the subject is unable to read or sign the informed consent, or unable to comprehend the information provided in the consent process, a legal guardian, decision making proxy, or next of kin must provide written consent, and if possible, subject must verbally assent to receiving an experimental treatment for their wound.
  2. Are at least 18 years of age.
  3. Are expected to remain in the Nursing Home for the duration of the study (22 days).
  4. Have one or more partial-thickness wounds (including wounds with excoriation, erosion or denuded skin, or ulceration to subcutaneous fat, but with no fascia, muscle, tendon or bone visible) on the trunk or proximal extremity (arm above the elbow, leg above the knee) which

    • have been present for at least 2 days but less than 6 weeks;
    • measure greater than or equal to 2 and less than or equal to40 cm2 in total denuded area; and,
    • are connected by areas of erythema (for multiple wounds).
  5. Are capable of maintaining an adequate nutritional intake during the study.
  6. Are in an acceptable state of health and nutrition with pre-albumin levels of greater than or equal to 15 mg/dl (0.015g/l), serum albumin greater than or equal to 3.0 g/dl (30g/l), alkaline phosphatase greater than or equal to the lower limit of normal, and have no abnormal laboratory values that, in the opinion of the Medical Supervisor, place the subject at risk for the study.

Exclusion Criteria:

  1. Have more than 64 cm2 of total denuded wound area, including target and non-target wounds.
  2. Have a full-thickness wound within 4 cm of any target wound.
  3. Have clinical evidence of bacterial or fungal infection of the target wound.
  4. Have target wound(s) that involves tunneling, sinus tracks, shear injury, arterial occlusive disease or bony prominence or joint with the exception that target wounds may be over dorsal spinous processes, coccyx, ischial tuberosities or sacroiliac joints (but may not be full thickness).
  5. Are moribund, or has a severe burn, immunodeficiency disorder, hematologic disorder, metastatic malignancy or uncontrolled diabetes mellitus.
  6. Are known to have acrodermatitis enteropathica (zinc deficiency).
  7. Are being treated with systemic steroids, immunosuppressive agents, radiation or chemotherapy.
  8. Have been treated with enzymatic debridement to the target wound(s) within 2 days prior to enrollment.
  9. Have a known sensitivity to ingredients of Xenaderm Ointment.
  10. Are using or have used another investigational agent (not including devices such as hearing aids, pace makers, etc.) within 30 days prior to Visit 1.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00714519

Sponsors and Collaborators
Healthpoint
Investigators
Study Chair: Herbert B Slade, MD Healthpoint
Study Director: Innes Cargill, PhD Healthpoint
  More Information

No publications provided

Responsible Party: Herbert Slade, MD/Chief Medical Officer, Healthpoint
ClinicalTrials.gov Identifier: NCT00714519     History of Changes
Other Study ID Numbers: 011-101-09-032
Study First Received: July 10, 2008
Last Updated: August 29, 2013
Health Authority: United States: Food and Drug Administration

Keywords provided by Healthpoint:
Xenaderm
partial
thickness
wounds
Nursing Homes

ClinicalTrials.gov processed this record on August 20, 2014