Speech and Language Therapy After Stroke

This study has been terminated.
(Protocol expired; PI retired)
Sponsor:
Collaborators:
Rehabilitation Institute of Chicago
Information provided by (Responsible Party):
University of Chicago
ClinicalTrials.gov Identifier:
NCT00713050
First received: July 9, 2008
Last updated: June 10, 2013
Last verified: June 2013
  Purpose

Our overall goal is to advance the state of functional brain imaging in aphasia, and then to apply the method to an intensive, imitation-based treatment for non-fluent aphasia.


Condition Intervention
Ischemic Stroke
Behavioral: Imitate Therapy

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double Blind (Subject, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Neurophysiological Measurement in Aphasia Treatment

Resource links provided by NLM:


Further study details as provided by University of Chicago:

Primary Outcome Measures:
  • Changes in scores on Western Aphasia Battery [ Time Frame: Four months ] [ Designated as safety issue: No ]

Enrollment: 34
Study Start Date: August 2007
Study Completion Date: January 2012
Primary Completion Date: January 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Experimental
Computer-based Aphasia therapy
Behavioral: Imitate Therapy
Imitation-based computer therapy
Other Name: Imitate
Active Comparator: Control
Control Arm - Healthy subjects.
Behavioral: Imitate Therapy
Imitation-based computer therapy
Other Name: Imitate

Detailed Description:

Detailed information will follow in the next progress report.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Single ischemic infarction in the MCA territory involving the cerebral cortex (confirmed by CT or MRI)
  2. Aphasia
  3. Visual attention and language comprehension sufficient to perform imitation fMRI tasks
  4. Right handed (prior to stroke)

Exclusion Criteria:

Exclusions to the study are people with cardiac pacemakers, claustrophobia, neurosurgical clips, or cognitive impairments too severe to permit cooperation with cognitive tasks in an MRI scanner.

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00713050

Locations
United States, California
University of California Irvine
Irvine, California, United States, 92697
Solodkin/Small Brain Circuits Laboratory
Irvine, California, United States, 92697
Sponsors and Collaborators
University of Chicago
Rehabilitation Institute of Chicago
Investigators
Principal Investigator: Steven Small, M.D., Ph.D. University of Chicago
  More Information

No publications provided

Responsible Party: University of Chicago
ClinicalTrials.gov Identifier: NCT00713050     History of Changes
Other Study ID Numbers: 13785A, 5R01DC007488-05
Study First Received: July 9, 2008
Last Updated: June 10, 2013
Health Authority: United States: Federal Government

Keywords provided by University of Chicago:
stroke
aphasia
imitation
mirror neuron

Additional relevant MeSH terms:
Stroke
Cerebral Infarction
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Brain Infarction
Brain Ischemia

ClinicalTrials.gov processed this record on July 23, 2014