Speech and Language Therapy After Stroke

This study is currently recruiting participants.

Verified by National Institute on Deafness and Other Communication Disorders (NIDCD), April 2009

First Received: July 9, 2008 Last Updated: April 22, 2009 History of Changes

Sponsor:	National Institute on Deafness and Other Communication Disorders (NIDCD)
Collaborator:	Rehabilitation Institute of Chicago
Information provided by:	National Institute on Deafness and Other Communication Disorders (NIDCD)
ClinicalTrials.gov Identifier:	NCT00713050

Purpose

Our overall goal is to advance the state of functional brain imaging in aphasia, and then to apply the method to an intensive, imitation-based treatment for non-fluent aphasia.

Condition	Intervention
Ischemic Stroke	Behavioral: Imitate Therapy

Study Type:	Interventional
Study Design:	Treatment, Randomized, Double Blind (Subject, Outcomes Assessor), Single Group Assignment
Official Title:	Neurophysiological Measurement in Aphasia Treatment

Resource links provided by NLM:

MedlinePlus related topics: Aphasia

U.S. FDA Resources

Further study details as provided by National Institute on Deafness and Other Communication Disorders (NIDCD):

Primary Outcome Measures:

Changes in scores on Western Aphasia Battery [ Time Frame: Four months ] [ Designated as safety issue: No ]

Estimated Enrollment:	57
Study Start Date:	August 2007
Estimated Study Completion Date:	August 2013
Estimated Primary Completion Date:	August 2013 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
Experimental: Experimental Experimental Arm	Behavioral: Imitate Therapy Imitation-based computer therapy
Control: Active Comparator Control Arm	Behavioral: Imitate Therapy Imitation-based computer therapy

Detailed Description:

Detailed information will follow in the next progress report.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Single ischemic infarction in the MCA territory involving the cerebral cortex (confirmed by CT or MRI)
Aphasia
Visual attention and language comprehension sufficient to perform imitation fMRI tasks
Right handed (prior to stroke)

Exclusion Criteria:

Exclusions to the study are people with cardiac pacemakers, claustrophobia, neurosurgical clips, or cognitive impairments too severe to permit cooperation with cognitive tasks in an MRI scanner.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00713050

Contacts

Contact: Blythe Buchholz, B.A.

773-834-7780

bbuchhol@neurology.bsd.uchicago.edu

Locations

United States, Illinois
University of Chicago	Recruiting
Chicago, Illinois, United States, 60637
Contact: Blythe Buchholz, B.A. 773-834-7780 bbuchhol@neurology.bsd.uchicago.edu
Principal Investigator: Steven Small, M.D., Ph.D.
Rehabilitation Institute of Chicago	Recruiting
Chicago, Illinois, United States, 60611

Sponsors and Collaborators

National Institute on Deafness and Other Communication Disorders (NIDCD)

Rehabilitation Institute of Chicago

Investigators

Principal Investigator:

Steven Small, M.D., Ph.D.

University of Chicago

More Information

Additional Information:

Related Info This link exits the ClinicalTrials.gov site

No publications provided

Responsible Party:	University of Chicago ( Dr. Steven Small, M.D., Ph.D. /Professor )
Study ID Numbers:	5R01DC7488-3
Study First Received:	July 9, 2008
Last Updated:	April 22, 2009
ClinicalTrials.gov Identifier:	NCT00713050 History of Changes
Health Authority:	United States: Federal Government

Keywords provided by National Institute on Deafness and Other Communication Disorders (NIDCD):

stroke
aphasia
imitation
mirror neuron

Additional relevant MeSH terms:

Cerebral Infarction
Nervous System Diseases
Stroke
Vascular Diseases
Brain Ischemia

Central Nervous System Diseases
Cardiovascular Diseases
Brain Infarction
Brain Diseases
Cerebrovascular Disorders

ClinicalTrials.gov processed this record on November 27, 2009