In Situ Caries Efficacy of Fluoride Toothpastes

Inclusion Criteria:

1. Consent Demonstrates understanding of the study and willingness to participate as evidenced by voluntary written informed consent and has received a signed and dated copy of the informed consent form.
2. Age Aged between 18 and 80 years.
3. Compliance Understands and is willing, able and likely to comply with all study procedures and restrictions.
4. General Health Good general health with (in the opinion of the investigator) no clinically significant and relevant abnormalities of medical history or physical examination.
5. Fluoride Currently living in the Indianapolis, Indiana area and not taking fluoride supplements for medical reasons

6. Dentures

   1. Currently wearing a removable mandibular partial denture with sufficient room in both posterior buccal flange areas to accommodate two enamel specimens on each side, four specimens in total - required dimensions 12 x 7 millimeter (mm) per side.
   2. Willing to have their denture modified to accommodate enamel test specimens and willing and capable of wearing their removable mandibular partial dentures 24 hours per day during the experimental periods
7. Dental health Have no current active caries or periodontal disease that may compromise the study or the health of the subjects and all restorations in a good state of repair
8. Salivary flow Have a salivary flow rate in the range of normal values (unstimulated whole saliva flow rate = 0.2 milliliter (mL)/minute; gum base stimulated whole saliva flow rate = 0.8 mL/minute)

Exclusion Criteria:

1. Pregnancy Women who are known to be pregnant or who are intending to become pregnant over the duration of the study.
2. Breast-feeding Women who are breast-feeding.
3. Allergy/Intolerance Known or suspected intolerance or hypersensitivity to the study materials (or closely related compounds) or any of their stated ingredients.
4. Antibiotics Currently taking antibiotics or have taken antibiotics in the two weeks prior to the screening visit

5. Clinical Study/Experimental Medication

   1. Participation in another clinical study or receipt of an investigational drug within 30 days of the screening visit.
   2. Participation in another GSKCH investigational dental product study within 7 days of first study treatment
   3. Previous participation in this study.
6. Substance abuse Recent history (within the last year) of alcohol or other substance abuse.

7. Personnel

   1. A member of the site study staff living in same household.
   2. An employee of the sponsor.
   3. Any employee of any toothpaste manufacturer or their spouse or family member