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Training-induced Cerebral Reorganization in Schizophrenia

This study has been completed.
Sponsor:
Collaborator:
German Research Foundation
Information provided by:
University of Konstanz
ClinicalTrials.gov Identifier:
NCT00695708
First received: June 9, 2008
Last updated: April 12, 2010
Last verified: June 2008
History of Changes
  Purpose

The purpose of this study is to reveal the effects of computer-aided cognitive-auditory training on cerebral reorganization in schizophrenia.


Condition Intervention
Schizophrenia
 Behavioral: Brain Fitness Program
Behavioral: Cogpack

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
Official Title: Training-induced Cerebral Reorganization in Schizophrenia

Resource links provided by NLM:

MedlinePlus related topics: Schizophrenia
U.S. FDA Resources

Further study details as provided by University of Konstanz:

Primary Outcome Measures:
  • Event related potential MEG, test scores in word fluency and verbal learning tasks [ Time Frame: pre and post intervention ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Symptom severity, GAF score [ Time Frame: pre and post intervention ] [ Designated as safety issue: No ]

Estimated Enrollment: 60
Study Start Date: January 2008
Study Completion Date: January 2010
Primary Completion Date: June 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: BFT
20 schizophrenic patients
 Behavioral: Brain Fitness Program
Computer-aided cognitive program designed for intensive training of auditory perception, memory and attention
Active Comparator: CP
19 schizophrenic patients
 Behavioral: Cogpack
Computer-aided cognitive program for cognitive abilities
No Intervention: HCG
20 healthy age and sex matched subjects

Detailed Description:

Impairment in cognitive functions is one of the main symptoms in schizophrenia and is currently one of the challenges in the treatment of the disease.

In this study we compare effects of two computer-aided training programs. One focused on auditory perception and processing as a basic ability underlying higher order information processing.

The other training involves a variability of cognitive abilities.

Both trainings are computer-aided and time-intensive, including up to twenty sessions within four weeks.

  Eligibility

Ages Eligible for Study:   up to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Clinical diagnosis of schizophrenia and disorders with psychotic features
  • Intact hearing abilities

Exclusion Criteria:

  • Mental retardation
  • Age over 60
  • Insufficient German language knowledge
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00695708

Locations
Germany
University of Konstanz
Konstanz, Baden Württenberg, Germany, 78457
Sponsors and Collaborators
University of Konstanz
German Research Foundation
Investigators
Study Chair: Brigitte Rockstroh, Prof. Dr. University of Konstanz, Department of Psychology
  More Information

No publications provided by University of Konstanz

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Responsible Party: Rockstroh Brigitte, Prof. Dr., University of Konstanz
ClinicalTrials.gov Identifier: NCT00695708     History of Changes
Other Study ID Numbers: RO 805/14
Study First Received: June 9, 2008
Last Updated: April 12, 2010
Health Authority: Germany: Ethics Commission

Keywords provided by University of Konstanz:
schizophrenia
neuroplasticity
sensory gating
 cognitive impairment
MEG
Disorders with Psychotic Features

Additional relevant MeSH terms:
Schizophrenia
Schizophrenia and Disorders with Psychotic Features
Mental Disorders

ClinicalTrials.gov processed this record on June 18, 2013