Investigation of the Immuno-regulation and Viral Hepatitis Among Patients With or After Dengue Fever Infection
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Purpose
The study will collect the blood samples from 350 healthy persons and 350 persons infected with dengue fever.
| Condition | Intervention |
|---|---|
|
Dengue Fever |
Genetic: CLEC5A |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control |
| Official Title: | Follow-up the Health Condition , Investigation of the Immuno-regulation , and the Study for Interaction of Viral Hepatitis--- Among Patients With or After Dengue Fever Infection |
| Estimated Enrollment: | 700 |
| Study Start Date: | July 2007 |
| Estimated Study Completion Date: | December 2014 |
| Estimated Primary Completion Date: | December 2014 (Final data collection date for primary outcome measure) |
| Groups/Cohorts | Assigned Interventions |
|---|---|
| healthy |
Genetic: CLEC5A
SNP (Single Nucleotide Polymorphism) genetic analysis of CLEC5A receptor (from exon 1 to exon 7)
|
| DF |
Genetic: CLEC5A
SNP (Single Nucleotide Polymorphism) genetic analysis of CLEC5A receptor (from exon 1 to exon 7)
|
| DHF |
Genetic: CLEC5A
SNP (Single Nucleotide Polymorphism) genetic analysis of CLEC5A receptor (from exon 1 to exon 7)
|
Detailed Description:
Research has showed that CLEC5A interacts with dengue virion directly, and is responsible for dengue virus (DV)-induced DAP12 phosphorylation. Data suggests that CLEC5A is a potential therapeutic target for dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). This project will study the genes of CLEC5A, Mannose receptor, DC-SIGN, NALP, decoy receptor 3 (DcR3), Toll-like receptors(TLRs), and (Nod)-like receptors (NLRs) for both DF and DHF groups. In addition, serum level of decoy receptor 3 (DcR3) will be tested. The study will collect the blood samples from 350 healthy persons and 350 persons infected with dengue fever.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
The samples are obtained from the Kaohsiung Medical University Chung-Ho Memorial Hospital in Kaohsiung, Taiwan.
Inclusion Criteria:
- Clinical diagnosis of Dengue fever
Exclusion Criteria:
- none
Contacts and Locations| Contact: Jih-Jin Tsai, MD | 886-7-312-1101 ext 5677 | jijits@cc.kmu.edu.tw |
| Taiwan | |
| Kaoshing Medical University Chung-Ho Memorial Hospital | Recruiting |
| Kaoshiung, Taiwan | |
| Contact: Jih-Jin Tsai, MD 886-7-312-1101 ext 5677 jijits@cc.kmu.edu.tw | |
More Information
No publications provided
| Responsible Party: | Kaohsiung Medical University Chung-Ho Memorial Hospital |
| ClinicalTrials.gov Identifier: | NCT00688389 History of Changes |
| Other Study ID Numbers: | KMUH-IRB-960195_1, CB9615 |
| Study First Received: | May 28, 2008 |
| Last Updated: | January 1, 2013 |
| Health Authority: | Taiwan: Institutional Review Board |
Keywords provided by Kaohsiung Medical University Chung-Ho Memorial Hospital:
|
Dengue fever, CLEC5A, Mannose receptor, DC-SIGN, NALP, decoy receptor 3 (DcR3), Toll-like receptors(TLRs), (Nod)-like receptors (NLRs) |
Additional relevant MeSH terms:
|
Dengue Hemorrhagic Fever Hemorrhagic Fevers, Viral Dengue Fever Hepatitis Hepatitis A Arbovirus Infections Virus Diseases Flavivirus Infections |
Flaviviridae Infections RNA Virus Infections Body Temperature Changes Signs and Symptoms Liver Diseases Digestive System Diseases Hepatitis, Viral, Human Enterovirus Infections Picornaviridae Infections |
ClinicalTrials.gov processed this record on May 23, 2013