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Comparison of On-line and Off-line Measurements of Exhaled Nitric Oxide (NO)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2009 by Ziv Hospital.
Recruitment status was  Not yet recruiting
Sponsor:
Information provided by:
Ziv Hospital
ClinicalTrials.gov Identifier:
NCT00686309
First received: May 26, 2008
Last updated: August 15, 2009
Last verified: August 2009
History of Changes
  Purpose

Asthma is a major health problem worldwide. The measurement of fractional exhaled nitric oxide (FENO) has been established as a valuable non invasive and simple tool in the diagnosis of asthma and may also act as a useful surrogate inflammatory marker on which to base treatment decisions in asthma management algorithms. The measurement is useful also in other respiratory diseases. Current methods of measuring FENO include on line measurements by heavy duty expensive analyzers which are not widely and easily available. Off line measurements of breath samples which can be analysed later may be a simple solution. We hypothesize tha toff line measurements of NO will be as reliable and valid as those measured on-line


Condition
Asthma
Primary Ciliary Dyskinesia

Study Type: Observational
Study Design: Observational Model: Case-Crossover
Time Perspective: Prospective
Official Title: Comparison of On-line and Off-line Measurements of Exhaled NO

Resource links provided by NLM:

MedlinePlus related topics: Asthma
U.S. FDA Resources

Further study details as provided by Ziv Hospital:

Primary Outcome Measures:
  • Off line measurement of exhaled NO [ Time Frame: Two types of breathing in the same day ] [ Designated as safety issue: No ]

Estimated Enrollment: 200
Study Start Date: July 2010
Estimated Study Completion Date: July 2011
Estimated Primary Completion Date: July 2011 (Final data collection date for primary outcome measure)
  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

General population bth healthy and with respiratory illness such as asthma, COPD, PCD, Rhinitis

Criteria

Inclusion Criteria:

  • Volunteer to participate
  • Filed a short health questionnaire

Exclusion Criteria:

  • None
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00686309

Contacts
Contact: Israel Amirav, MD 972-4-682-8712 amirav@012.net.il

Locations
Israel
Pediatric Department, Ziv Medical Center Not yet recruiting
Safed, Israel
Contact: Israel Amirav, MD     972-4-682-8712     amirav@012.net.il    
Principal Investigator: Israel Amirav, MD            
Sponsors and Collaborators
Ziv Hospital
  More Information

No publications provided

Responsible Party: Israel Amirav, Ziv Medical center
ClinicalTrials.gov Identifier: NCT00686309     History of Changes
Other Study ID Numbers: HP8-295-R
Study First Received: May 26, 2008
Last Updated: August 15, 2009
Health Authority: Israel: Ministry of Health

Keywords provided by Ziv Hospital:
exhaled NO
off line
on line
comparison
Bland altman method

Additional relevant MeSH terms:
Asthma
Ciliary Motility Disorders
Kartagener Syndrome
Dyskinesias
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases
Otorhinolaryngologic Diseases
Bronchiectasis
 Respiratory System Abnormalities
Dextrocardia
Heart Defects, Congenital
Cardiovascular Abnormalities
Cardiovascular Diseases
Heart Diseases
Congenital Abnormalities
Situs Inversus
Genetic Diseases, Inborn
Movement Disorders
Central Nervous System Diseases
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms

ClinicalTrials.gov processed this record on May 21, 2013