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| Sponsors and Collaborators: |
Sunnybrook Health Sciences Centre Ontario Centres of Excellence |
|---|---|
| Information provided by: | Sunnybrook Health Sciences Centre |
| ClinicalTrials.gov Identifier: | NCT00685438 |
Purpose
With the increasing tourism and adventure travel into extreme environments comes the need to reassess the required protection against ultraviolet (UV) radiation and possible other oxidative stresses. This is an observational study of UV radiation exposure and skin erythema while at extreme altitude (Mt. Everest). In addition to UV exposure, skin erythema, antioxidant use (such as vitamins C and E) will be measured.
Hypothesis:
| Condition |
|---|
|
Altitude Ultraviolet Rays Antioxidants Oxidative Stress Erythema |
| Study Type: | Observational |
| Study Design: | Ecologic or Community, Prospective |
| Official Title: | Observational Study of Skin Erythema by Spectrophotometer, and UV Exposure With Viospore Ultraviolet Monitors at Extreme Altitude (Mt. Everest, North Side) |
| Enrollment: | 25 |
| Study Start Date: | April 2007 |
| Study Completion Date: | June 2007 |
The literature widely acknowledges the deleterious effects of UV radiation on skin health, via production of oxidative free radicals. Consequently, there have been numerous studies on the potential dermatological/anti-carcinogenic benefits of anti-oxidants, such as vitamins C and E, melatonin, green tea, zinc, and selenium. There is, however, a limited amount of literature on the quantity of UV exposure in high-risk settings, such as extreme altitude and equatorial zones. Currently, there is no literature on UV exposure on Mount Everest. Additionally, the efficacy of antioxidants (topical or systemic) has not yet been established in this environment.
This will be an observational study where the principal investigator will collect accumulated ultraviolet exposure at different extreme altitudes during a 6 week period of a summit expedition on the north side of Mt. Everest. Included in the data collection will be patient demographics, time, altitude, temperature, use of anti-oxidants, sunscreen (weighed), and skin erythema (spectophotometer).
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
9 Mountaineers with intention to summit Everest (1 American, 1 British, 1 German, 5 Australians, 1 Asian-Australian) 4 Trekkers with intention to go to 7000m (2 Americans, 1 Asian, 1 British) 12 climbing sherpas (11 Nepali and 1 Tibetan)
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Nepal | |
| Mount Everest, North side | |
| Kathmandu, Nepal | |
| Principal Investigator: | Ivy S Cheng, MD | Sunnybrook Hospital Emergency Department |
| Principal Investigator: | Lothar D Lilge, PhD | Ontario Cancer Institute |
More Information
| Responsible Party: | Sunnybrook Health Sciences Center ( Ivy Cheng ) |
| Study ID Numbers: | 005-2007 |
| Study First Received: | May 22, 2008 |
| Last Updated: | May 27, 2008 |
| ClinicalTrials.gov Identifier: | NCT00685438 History of Changes |
| Health Authority: | Canada: Ethics Review Committee |
|
Environmental Medicine Altitude Ultraviolet Rays |
Antioxidants Oxidative Stress Erythema |
|
Erythema Antioxidants Skin Diseases Stress |
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Erythema Antioxidants Molecular Mechanisms of Pharmacological Action Skin Diseases |
Physiological Effects of Drugs Protective Agents Pharmacologic Actions |