Cerebellar Loops and Attention Deficit Hyperactivity Disorder (ADHD) - Full Text View

Sponsor:	University Hospital, Bordeaux
Information provided by:	University Hospital, Bordeaux
ClinicalTrials.gov Identifier:	NCT00684931

Purpose

The aim of this study is to investigate the integrity of connectivity between the neocortex and the cerebellum in the Attention Deficit Hyperactivity Disorder (ADHD). Fibers integrity will be measured using magnetic Resonance Imaging Techniques.

Condition	Intervention
Attention Deficit Disorder With Hyperactivity	Other: Imaging

Study Type:	Interventional
Study Design:	Basic Science, Non-Randomized, Open Label, Parallel Assignment
Official Title:	Alterations of Fronto-Cerebello-Frontal Loops in Attention Deficit Hyperactivity Disorder (ADHD) : A Study Using Magnetic Resonance Imaging (MRI)

Resource links provided by NLM:

MedlinePlus related topics: Attention Deficit Hyperactivity Disorder MRI Scans

U.S. FDA Resources

Further study details as provided by University Hospital, Bordeaux:

Primary Outcome Measures:

Fractional anisotropy coefficient if fronto-cerebello-frontal loops. [ Time Frame: visite 1 ] [ Designated as safety issue: No ]

Enrollment:	19
Study Start Date:	February 2008
Study Completion Date:	July 2008
Primary Completion Date:	February 2008 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
1: Experimental patients with Attention Deficit Disorder with or without Hyperactivity	Other: Imaging neuropsychological evaluation and Imaging with magnetic resonance (MRI)
2: Sham Comparator healthy volunteer without Attention Deficit Hyperactivity Disorder	Other: Imaging neuropsychological evaluation and Imaging with magnetic resonance (MRI)

Detailed Description:

ADHD is a neurodevelopmental trouble characterized by attentional deficits, impulsivity and motor hyperactivity. Morphological neuroimaging studies in ADHD children have revealed cerebellar abnormalities, however data in adults regarding cerebellum alterations are scarce. In this study we will analyse the conectivity of the cerebellum of adults ADHD patients. We will use diffusion tensor imaging (DTI) technique, and morphological data will be compared with the neuropsychological status.

Eligibility

Ages Eligible for Study:	18 Years to 35 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Patient with ADHD :

Diagnosis of ADHD
18 - 35 years old

Healthy volunteer :

18 - 35 years old
no ADHD diagnosed

Exclusion Criteria:

Associated neurological or psychiatric pathologies
Pregnant woman
MRI counter indication

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00684931

Locations

France
Charles Perrens Hospital
Bordeaux, France, 33000
University Hospital Bordeaux
Bordeaux, France, 33076

Sponsors and Collaborators

University Hospital, Bordeaux

Investigators

Principal Investigator:

Manuel BOUVARD, MD

Charles Perrens Hospital

More Information

No publications provided

Responsible Party:	University Hospital, Bordeaux ( Jean-Pierre LEROY / Clinical Research and Innovation Director )
Study ID Numbers:	CHUBX 2007/21
Study First Received:	May 22, 2008
Last Updated:	June 22, 2009
ClinicalTrials.gov Identifier:	NCT00684931 History of Changes
Health Authority:	France: Direction Générale de la Santé

Keywords provided by University Hospital, Bordeaux:

Attention
Deficit
Disorder
Hyperactivity

cerebellum
alteration
fronto-cerebello-frontal loops

Additional relevant MeSH terms:

Signs and Symptoms
Pathologic Processes
Disease
Attention Deficit Disorder with Hyperactivity
Mental Disorders
Nervous System Diseases

Mental Disorders Diagnosed in Childhood
Neurologic Manifestations
Attention Deficit and Disruptive Behavior Disorders
Hyperkinesis
Dyskinesias

ClinicalTrials.gov processed this record on November 30, 2009