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Cerebellar Loops and Attention Deficit Hyperactivity Disorder (ADHD) (TDA/H)

This study is currently recruiting participants.
Verified by University Hospital, Bordeaux, May 2008

Sponsored by: University Hospital, Bordeaux
Information provided by: University Hospital, Bordeaux
ClinicalTrials.gov Identifier: NCT00684931
  Purpose

The aim of this study is to investigate the integrity of connectivity between the neocortex and the cerebellum in the Attention Deficit Hyperactivity Disorder (ADHD). Fibers integrity will be measured using magnetic Resonance Imaging Techniques.


Condition Intervention
Attention Deficit Disorder With Hyperactivity
Other: Imaging

MedlinePlus related topics:   Attention Deficit Hyperactivity Disorder    MRI Scans   

U.S. FDA Resources

Study Type:   Interventional
Study Design:   Basic Science, Non-Randomized, Open Label, Parallel Assignment
Official Title:   Alterations of Fronto-Cerebello-Frontal Loops in Attention Deficit Hyperactivity Disorder (ADHD) : A Study Using Magnetic Resonance Imaging (MRI)

Further study details as provided by University Hospital, Bordeaux:

Primary Outcome Measures:
  • Fractional anisotropy coefficient if fronto-cerebello-frontal loops. [ Time Frame: visite 1 ] [ Designated as safety issue: No ]

Estimated Enrollment:   40
Study Start Date:   February 2008
Estimated Study Completion Date:   May 2011
Estimated Primary Completion Date:   May 2011 (Final data collection date for primary outcome measure)

Arms Assigned Interventions
1: Experimental
patients with Attention Deficit Disorder with or without Hyperactivity
Other: Imaging
neuropsychological evaluation and Imaging with magnetic resonance (MRI)
2: Sham Comparator
healthy volunteer without Attention Deficit Hyperactivity Disorder
Other: Imaging
neuropsychological evaluation and Imaging with magnetic resonance (MRI)

Detailed Description:

ADHD is a neurodevelopmental trouble characterized by attentional deficits, impulsivity and motor hyperactivity. Morphological neuroimaging studies in ADHD children have revealed cerebellar abnormalities, however data in adults regarding cerebellum alterations are scarce. In this study we will analyse the conectivity of the cerebellum of adults ADHD patients. We will use diffusion tensor imaging (DTI) technique, and morphological data will be compared with the neuropsychological status.

  Eligibility
Ages Eligible for Study:   18 Years to 35 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Criteria

Inclusion Criteria:

Patient with ADHD :

  • Diagnosis of ADHD
  • 18 - 35 years old

Healthy volunteer :

  • 18 - 35 years old
  • no ADHD diagnosed

Exclusion Criteria:

  • Associated neurological or psychiatric pathologies
  • Pregnant woman
  • MRI counter indication
  Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00684931

Contacts
Contact: Manuel BOUVARD, MD     05.56.56.17.19     manuel.bouvard@wanadoo.fr    
Contact: Willy MAYO, MD     05.57.82.04.53     willy.mayo@bordeaux.inserm.fr    

Locations
France
Charles Perrens Hospital     Recruiting
      Bordeaux, France, 33000
      Contact: Manuel BOUVARD, MD     05.56.56.17.19     manuel.bouvard@wanadoo.fr    
      Contact: Jean-Philippe RENERIC, MD         jean-philippe.reneric@chu-bordeaux.fr    
      Sub-Investigator: Jean-Philippe RENERIC, MD            
University Hospital Bordeaux     Recruiting
      Bordeaux, France, 33076
      Contact: Michèle ALLARD, MD     05.56.79.55.40     michele.allard@chu-bordeaux.fr    
      Contact: Willy MAYO, MD     05.57.82.04.53     willy.mayo@bordeaux.inserm.fr    
      Principal Investigator: Michèle ALLARD, MD            

Sponsors and Collaborators
University Hospital, Bordeaux

Investigators
Principal Investigator:     Manuel BOUVARD, MD     Charles Perrens Hospital    
  More Information

Responsible Party:   University Hospital, Bordeaux ( Jean-Pierre LEROY / Clinical Research and Innovation Director )
Study ID Numbers:   CHUBX 2007/21
First Received:   May 22, 2008
Last Updated:   May 22, 2008
ClinicalTrials.gov Identifier:   NCT00684931
Health Authority:   France: Direction Générale de la Santé

Keywords provided by University Hospital, Bordeaux:
Attention  
Deficit  
Disorder  
Hyperactivity  
cerebellum
alteration
fronto-cerebello-frontal loops

Study placed in the following topic categories:
Signs and Symptoms
Attention Deficit Disorder with Hyperactivity
Mental Disorders
Mental Disorders Diagnosed in Childhood
Neurologic Manifestations
Attention Deficit and Disruptive Behavior Disorders
Hyperkinesis
Dyskinesias

Additional relevant MeSH terms:
Pathologic Processes
Disease
Nervous System Diseases

ClinicalTrials.gov processed this record on August 29, 2008




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