Cerebellar Loops and Attention Deficit Hyperactivity Disorder (ADHD) - Full Text View

Purpose

The aim of this study is to investigate the integrity of connectivity between the neocortex and the cerebellum in the Attention Deficit Hyperactivity Disorder (ADHD). Fibers integrity will be measured using magnetic Resonance Imaging Techniques.

Condition	Intervention
Attention Deficit Disorder With Hyperactivity	Other: Imaging

MedlinePlus related topics:

Attention Deficit Hyperactivity Disorder MRI Scans

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Basic Science, Non-Randomized, Open Label, Parallel Assignment

Official Title:	Alterations of Fronto-Cerebello-Frontal Loops in Attention Deficit Hyperactivity Disorder (ADHD) : A Study Using Magnetic Resonance Imaging (MRI)

Further study details as provided by University Hospital, Bordeaux:

Primary Outcome Measures:

Fractional anisotropy coefficient if fronto-cerebello-frontal loops. [ Time Frame: visite 1 ] [ Designated as safety issue: No ]

Estimated Enrollment:	40
Study Start Date:	February 2008
Estimated Study Completion Date:	May 2011
Estimated Primary Completion Date:	May 2011 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
1: Experimental patients with Attention Deficit Disorder with or without Hyperactivity	Other: Imaging neuropsychological evaluation and Imaging with magnetic resonance (MRI)
2: Sham Comparator healthy volunteer without Attention Deficit Hyperactivity Disorder	Other: Imaging neuropsychological evaluation and Imaging with magnetic resonance (MRI)

Detailed Description:

ADHD is a neurodevelopmental trouble characterized by attentional deficits, impulsivity and motor hyperactivity. Morphological neuroimaging studies in ADHD children have revealed cerebellar abnormalities, however data in adults regarding cerebellum alterations are scarce. In this study we will analyse the conectivity of the cerebellum of adults ADHD patients. We will use diffusion tensor imaging (DTI) technique, and morphological data will be compared with the neuropsychological status.

Eligibility

Ages Eligible for Study:	18 Years to 35 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Patient with ADHD :

Diagnosis of ADHD
18 - 35 years old

Healthy volunteer :

18 - 35 years old
no ADHD diagnosed

Exclusion Criteria:

Associated neurological or psychiatric pathologies
Pregnant woman
MRI counter indication

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00684931

Contacts


Contact: Manuel BOUVARD, MD	05.56.56.17.19	manuel.bouvard@wanadoo.fr

Contact: Willy MAYO, MD	05.57.82.04.53	willy.mayo@bordeaux.inserm.fr

Locations


France
	Charles Perrens Hospital	Recruiting
	Bordeaux, France, 33000
	Contact: Manuel BOUVARD, MD 05.56.56.17.19 manuel.bouvard@wanadoo.fr
	Contact: Jean-Philippe RENERIC, MD jean-philippe.reneric@chu-bordeaux.fr
	Sub-Investigator: Jean-Philippe RENERIC, MD
	University Hospital Bordeaux	Recruiting
	Bordeaux, France, 33076
	Contact: Michèle ALLARD, MD 05.56.79.55.40 michele.allard@chu-bordeaux.fr
	Contact: Willy MAYO, MD 05.57.82.04.53 willy.mayo@bordeaux.inserm.fr
	Principal Investigator: Michèle ALLARD, MD

Sponsors and Collaborators

University Hospital, Bordeaux

Investigators


Principal Investigator:	Manuel BOUVARD, MD	Charles Perrens Hospital

More Information

Responsible Party:	University Hospital, Bordeaux ( Jean-Pierre LEROY / Clinical Research and Innovation Director )
Study ID Numbers:	CHUBX 2007/21
First Received:	May 22, 2008
Last Updated:	May 22, 2008
ClinicalTrials.gov Identifier:	NCT00684931
Health Authority:	France: Direction Générale de la Santé

Keywords provided by University Hospital, Bordeaux:

Attention

Deficit

Disorder

Hyperactivity

cerebellum

alteration

fronto-cerebello-frontal loops

Study placed in the following topic categories:

Signs and Symptoms

Attention Deficit Disorder with Hyperactivity

Mental Disorders

Mental Disorders Diagnosed in Childhood

Neurologic Manifestations

Attention Deficit and Disruptive Behavior Disorders

Hyperkinesis

Dyskinesias

Additional relevant MeSH terms:

Pathologic Processes

Disease

Nervous System Diseases

ClinicalTrials.gov processed this record on August 29, 2008

Sponsored by:	University Hospital, Bordeaux
Information provided by:	University Hospital, Bordeaux
ClinicalTrials.gov Identifier:	NCT00684931