Metabolic Derangements in Acute Heart Failure Syndrome

This study has been terminated.
(Project not initiated)
Sponsor:
Information provided by:
The Cleveland Clinic
ClinicalTrials.gov Identifier:
NCT00682175
First received: May 20, 2008
Last updated: March 25, 2009
Last verified: March 2009
  Purpose

To determine the association of both neurohormonal and hemodynamic alterations associated with metabolic abnormalities in acute heart failure syndrome.


Condition Intervention
Congestive Heart Failure
Other: Observational

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Metabolic Derangements in Acute Heart Failure Syndrome

Resource links provided by NLM:


Further study details as provided by The Cleveland Clinic:

Biospecimen Retention:   Samples Without DNA

serum, plasma


Estimated Enrollment: 100
Study Start Date: May 2008
Study Completion Date: March 2009
Primary Completion Date: March 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Observation
Adult (age > 18 yrs) patients admitted to the Heart Failure Intensive Care Unit with Acute Heart Failure Syndrome requiring placement of a Pulmonary Artery catheter for hemodynamically guided therapy.
Other: Observational
Pulmonary Artery pressure (PA), pulmonary capillary wedge pressure (PCWP), cardiac output (CO), and cardiac index (CI). This data will be collected after 24 ± 2 and 48 ± 2 hours of standard heart failure therapy

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Adult (age > 18 yrs) patients admitted to the Heart Failure Intensive Care Unit (H22) with Acute Heart Failure Syndrome (AHFS) requiring placement of a Pulmonary Artery catheter for hemodynamically guided therapy.

Criteria

Inclusion Criteria:

  • Adult (age > 18 yrs) patients admitted to the Heart Failure Intensive Care Unit (H22) with Acute Heart Failure Syndrome (AHFS) requiring placement of a Pulmonary Artery catheter for hemodynamically guided therapy.

Exclusion Criteria:

  • History of Congenital Heart Disease.
  • Acute HF in the setting of acute myocardial infarction.
  • Severe Anemia
  • Patients listed for cardiac transplantation.
  • Terminal Malignancy, AIDS or CNS disease.
  • Concomitant sepsis, ARDS, trauma, aortic dissection, or pericardial tamponade
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00682175

Sponsors and Collaborators
The Cleveland Clinic
Investigators
Principal Investigator: George Sokos, MD The Cleveland Clinic
  More Information

No publications provided

Responsible Party: George Sokos, MD, Cleveland Clinic Foundation
ClinicalTrials.gov Identifier: NCT00682175     History of Changes
Other Study ID Numbers: 08-169
Study First Received: May 20, 2008
Last Updated: March 25, 2009
Health Authority: United States: Institutional Review Board

Keywords provided by The Cleveland Clinic:
Congestive Heart Failure

Additional relevant MeSH terms:
Heart Failure
Heart Diseases
Cardiovascular Diseases

ClinicalTrials.gov processed this record on April 17, 2014