Joint Stiffness Following Knee Replacement Surgery

This study is currently recruiting participants. (see Contacts and Locations)
Verified June 2011 by Ottawa Hospital Research Institute
Sponsor:
Information provided by:
Ottawa Hospital Research Institute
ClinicalTrials.gov Identifier:
NCT00664651
First received: April 21, 2008
Last updated: June 13, 2011
Last verified: June 2011
  Purpose

Our primary research question is to find out whether there is a genetic component to the development of joint contractures following knee surgery, through the application of lab techniques.


Condition
Joint Contracture

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Retrospective
Official Title: Capsular Changes in Joint Contractures Post-Knee Arthroplasty:A Case-Control Study

Resource links provided by NLM:


Further study details as provided by Ottawa Hospital Research Institute:

Estimated Enrollment: 120
Study Start Date: December 2006
Estimated Study Completion Date: December 2015
Detailed Description:

After total knee replacement surgery, some people develop joint stiffness, which is also called a joint contracture. Contractures cause the envelope of the knee (called the capsule) to stiffen and become rigid so the patient can no longer move their knee the way they used to. After stretching and other exercises, only a surgery can try and divide or remove the contracture. The main purpose of this research is to study the cause of the contracture and specifically if certain people are predisposed to contractures.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

joint contractures following knee surgery

Criteria

Inclusion Criteria:

-knee contractures post arthroplasty scheduled for arthrotomy with debridement of capsular tissue Controls will be patients scheduled for arthrotomy with debridement of capsular tissue for the other reasons(primary knee arthroplasty, ORIF of the knee secondary to trauma, ACL repair, amputation, elective joint arthroplasty with capsuloplasty etc.)

Exclusion:

  • transmissible disease (HIV, Hep B,C)
  • confirmed or suspected neoplasia
  • suspected infection
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00664651

Contacts
Contact: Guy Trudel (613) 737-7350

Locations
Canada, Ontario
Ottawa Hospital Research Institute Recruiting
Ottawa, Ontario, Canada, K1Y 4E9
Contact: Guy Trudel, MD    613-737-8899 ext 77350    gtrudel@ottawahospital.on.ca   
Sponsors and Collaborators
Ottawa Hospital Research Institute
Investigators
Principal Investigator: Guy Trudel, MD,MSc,FRCPC OHRI / The Ottawa Hospital
  More Information

No publications provided

Responsible Party: Dr. Guy Trudel, OHRI
ClinicalTrials.gov Identifier: NCT00664651     History of Changes
Other Study ID Numbers: 2006541
Study First Received: April 21, 2008
Last Updated: June 13, 2011
Health Authority: Canada: Ethics Review Committee

Keywords provided by Ottawa Hospital Research Institute:
joint contracture
total knee arthroplasty

Additional relevant MeSH terms:
Contracture
Joint Diseases
Musculoskeletal Diseases
Muscular Diseases

ClinicalTrials.gov processed this record on August 28, 2014