Pharmacology and Physiology of the Lower Urinary Tract

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2008 by University College London Hospitals.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
University College London Hospitals
ClinicalTrials.gov Identifier:
NCT00662064
First received: April 16, 2008
Last updated: June 19, 2008
Last verified: June 2008
  Purpose

The function of the lower urinary tract is simple - urine storage and voiding. However, despite this simplicity of function, the control of the lower urinary tract is a rather complex, multilevel process (urothelium, detrusor, peripheral nerves, spinal cord and higher cerebral centres) and the mechanisms involved remain poorly elucidated.

This study is designed to gain a more in depth understanding of the lower urinary tract function. Using bladder biopsies, tissue staining for characteristic markers present on nerves and other cells will be performed. We hypothesize that certain markers are altered in disease and turn back towards the control level of healthy people or patients with successful medical treatment.


Condition
Urologic Diseases

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Pharmacology and Physiology of the Lower Urinary Tract

Further study details as provided by University College London Hospitals:

Primary Outcome Measures:
  • Immunohistochemistry + PCR of bladder tissue [ Time Frame: not specified (storage of biopsies) ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples Without DNA

bladder biopsies from patients with lower urinary tract dysfunction and from healthy controls


Estimated Enrollment: 200
Study Start Date: February 2002
Estimated Study Completion Date: December 2008
Estimated Primary Completion Date: December 2008 (Final data collection date for primary outcome measure)
Groups/Cohorts
1
Patients with lower urinary tract dysfunction
2
Controls with normal lower urinary tract function

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Patients with lower urinary tract dysfunction and controls with normal lower urinary tract function

Criteria

Inclusion Criteria:

  • Patients with lower urinary tract dysfunction
  • Controls with normal lower urinary tract function

Exclusion Criteria:

  • Age < 18 years old
  • Pregnancy
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00662064

Contacts
Contact: Thomas M Kessler, MD 44-207-829-8713 ext 8713 tkessler@gmx.ch
Contact: Shahid Khan, MD 44-207-829-8713 ext 8713 drshahidkhan@gmail.com

Locations
United Kingdom
Department of Uro-Neurology, The National Hospital for Neurology and Neurosurgery Recruiting
London, United Kingdom, WC1N 3BG
Contact: Thomas M Kessler, MD    44-207-829-8713 ext 8713    tkessler@gmx.ch   
Contact: Shahid Khan, MD    44-207-829-8713 ext 8713    drshahidkhan@gmail.com   
Principal Investigator: Clare J Fowler, FRCP         
Sponsors and Collaborators
University College London Hospitals
Investigators
Principal Investigator: Clare J Fowler, FRCP Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, University College London Hospitals, London, UK
Principal Investigator: Suzy Elneil, PhD, MRCOG Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, University College London Hospitals, London, UK
  More Information

No publications provided by University College London Hospitals

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Prof C J Fowler, Prof C H Fry, Dep Uro-Neurology, National Hospital for Neurology and Neurosurgery, London, UK
ClinicalTrials.gov Identifier: NCT00662064     History of Changes
Other Study ID Numbers: 00/0039
Study First Received: April 16, 2008
Last Updated: June 19, 2008
Health Authority: United Kingdom: National Health Service

Keywords provided by University College London Hospitals:
Lower urinary tract
Physiology
Pathology
Immunohistochemistry
Urinary bladder

Additional relevant MeSH terms:
Urologic Diseases

ClinicalTrials.gov processed this record on August 19, 2014