Optimizing Drug-Therapy in Patients 80 Years and Older

This study has been completed.
Sponsor:
Collaborator:
Uppsala University
Information provided by:
Uppsala University Hospital
ClinicalTrials.gov Identifier:
NCT00661310
First received: April 14, 2008
Last updated: December 4, 2008
Last verified: October 2008
  Purpose

The purpose of this study is to measure the effects of an enhanced service where a pharmacists is part of the healthcare team on the ward (focusing on drug-related problems and transferring information between primary and secondary care). Primary outcome measure is visits to hospital during a 12-month follow-up period, and the population is patients 80 years and older.


Condition Intervention
Drug-Related Problems
Other: Drug review 80+ -To reduce usage of hospital care

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Health Services Research
Official Title: Optimizing Drug-Therapy in Patients, 80 Years and Older, in Order to Reduce Drug-Related Morbidity and Usage of Secondary Care - a Randomized Controlled Trial

Further study details as provided by Uppsala University Hospital:

Primary Outcome Measures:
  • Effects on hospital visits [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]

Enrollment: 400
Study Start Date: September 2005
Study Completion Date: June 2007
Primary Completion Date: June 2006 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: I
Intervention by team consisting of Doctor, pharmacist and nurse
Other: Drug review 80+ -To reduce usage of hospital care
drug review performed by multiprofessional team, including clinical pharmacist, in order to optimize drug therapy and reduce usage of hospital care. Also patient education and follow-up
No Intervention: C

Detailed Description:

Optimising drug-therapy for patients, 80 years and older, to reduce hospital visits

Background and Objective:

Results from a pilot-study performed in 2004 at the Academic Hospital, Uppsala, including 214 consecutive patients (80 years old or older) showed that 9.4%-13.6% of the patients were acutely admitted to hospital due to a drug related problem1. Other similar international studies show that the frequency of drug-related hospital admissions stands for at least 14% of the acute admissions (14%-30.4%). Of these admissions it was estimated that 32%-69% were preventable 2,3,4.

A study from Antrim Hospital, Northern Ireland, showed that pharmacists´ involvement in the health care team can reduce the number of acute hospital admissions and improve quality of drug use5.

In view of these findings this study was initiated in 2005 with fundings from the Drug and Therapeutics committee, the County Council of Uppsala, the Division of Acute-Medicine and the Pharmacy Department at the Academic Hospital in Uppsala

Aim and objectives:

The Study Aim was to optimize drug-prescribing and drug use for patients 80 years and older.

The main objective was to reduce the number of hospital visits for patients 80-years old or older.

Design:

A randomized, controlled trial including 400 patients (200+200). Patients in the intervention group (I) received a patient interview on admission, drug counseling on discharge and a drug review - all performed by a clinical pharmacist. Patients in the control group (C) received standard care, without pharmacists´ involvement.

Patients were included between Oct 2005 and June 2006.

Setting:

Two wards at the Division of Acute-Medicine at Uppsala University Hospital, Sweden

Main Outcome Measures:

1) Frequency of hospital visits 12 months after (last included patient) discharge from hospital for (I) and (C).

  Eligibility

Ages Eligible for Study:   80 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • 80 years and older
  • Acute admission to study ward

Exclusion Criteria:

  • <80 years
  • Scheduled admission
  • Previously admitted to studyward during study period
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00661310

Locations
Sweden
Uppsala University hospital
Uppsala, Sweden, 75185
Sponsors and Collaborators
Uppsala University Hospital
Uppsala University
Investigators
Principal Investigator: Henrik Toss, MD PhD Uppsala University Hospital
  More Information

No publications provided by Uppsala University Hospital

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Henrik Toss, MD, PhD, Uppsala University Hospital
ClinicalTrials.gov Identifier: NCT00661310     History of Changes
Other Study ID Numbers: Uppsala80
Study First Received: April 14, 2008
Last Updated: December 4, 2008
Health Authority: Sweden: Institutional Review Board

Keywords provided by Uppsala University Hospital:
re-admissions
medicines
management
patients
80 years and older
acute
admissions
hospital

ClinicalTrials.gov processed this record on July 26, 2014