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| Sponsor: | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
|---|---|
| Collaborators: |
University of Florida Emory University Medical University of South Carolina University of South Carolina |
| Information provided by: | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
| ClinicalTrials.gov Identifier: | NCT00649246 |
Purpose
This is an observational study designed to help researchers understand the genetics and pathogenesis of type 1 diabetes, and to identify biomarkers for disease and disease complication prediction.
| Condition |
|---|
|
Type 1 Diabetes Autoimmunity |
| Study Type: | Observational |
| Study Design: | Cohort, Prospective |
| Official Title: | 1. Prospective Studies in Infants of the Immunopathogenesis of Type 1 Diabetes 2. Consortium for Identification of Environmental Triggers of Type 1 Diabetes: MCG/UF Clinical Center 3. Identification of Serum Protein Markers for Type 1 Diabetes Using Mass-Spectrometry Techniques 4. Validation of Microarray-Based Biomarkers for Type 1 Diabetes 5. Development of Microarray-Based Biomarkers for Type 1 Diabetes 6. Proteomic Changes/Progression of Human Type 1 Diabetes 7. Identification and Validation of Serum Biomarkers for T1D |
whole blood, DNA, serum, RNA, urine
| Estimated Enrollment: | 50000 |
| Study Start Date: | July 1997 |
| Groups/Cohorts |
|---|
|
1
controls: healthy individuals with no family history of type 1 diabetes |
|
2
high-risk: Subjects with islet autoantibodies or high-risk diabetes genes |
|
3
type 1 diabetes: subjects with type 1 diabetes |
This study is designed to identify people who are at risk for developing type 1 diabetes, based on their genetics, family history and autoimmunity status, and to understand the role genetics plays in the development of the complications associated with type 1 diabetes in patients already affected by type 1 diabetes.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
newborns, young children, adults with or without type 1 diabetes
Inclusion Criteria: all are welcome -
Exclusion Criteria:
-
Contacts and Locations| Contact: Diane I Hopkins, MS, CCRC | 706-721-4161 | dhopkins@mcg.edu |
| Contact: Leigh Steed, RN, CCRA | 404-252-0844 | lsteed@mcg.edu |
| United States, Florida | |
| University of Florida | Recruiting |
| Gainesville, Florida, United States, 32608 | |
| Contact: Angie Choate, BS 352-334-0843 choatal@peds.ufl.edu | |
| Contact: Angela Wilcox, BS 352-334-0843 | |
| Principal Investigator: Desmond Schatz, MD | |
| United States, South Carolina | |
| Medical University of South Carolina | Recruiting |
| Charleston, South Carolina, United States, 29425 | |
| Contact: Lori Spillers, RN 843-792-8166 spillerl@musc.edu | |
| Principal Investigator: Louis Luttrel, MD | |
| University of South Carolina | Recruiting |
| Columbia, South Carolina, United States, 29208 | |
| Contact: Joan Thomas 803-251-7870 jthomas@gwm.sc.edu | |
| Principal Investigator: Elizabeth Mayer-Davis, PhD | |
| Principal Investigator: | Jin Xiong She, PhD | Medical College of Georgia |
More Information
| Responsible Party: | Center for Biotechnology and Genomic Medicine at the Medical College of Georgia ( Jin Xiong She Ph.D. ) |
| Study ID Numbers: | DK63865 - PANDA |
| Study First Received: | March 28, 2008 |
| Last Updated: | September 14, 2009 |
| ClinicalTrials.gov Identifier: | NCT00649246 History of Changes |
| Health Authority: | United States: Federal Government |
|
genetics type 1 diabetes biomarkers autoimmunity |
|
Diabetes Mellitus, Type 1 Autoimmune Diseases Metabolic Diseases Immune System Diseases |
Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders |
