Incretin Secretion in Women With Polycystic Ovary Syndrome (PCOS)

This study has been terminated.
Sponsor:
Collaborator:
University of Copenhagen
Information provided by:
Hvidovre University Hospital
ClinicalTrials.gov Identifier:
NCT00647023
First received: March 26, 2008
Last updated: NA
Last verified: March 2008
History: No changes posted
  Purpose

The incretin hormones are secreted from the gastrointestinal tract in response to nutrient ingestion, and are responsible for 70 % of insulin secretion in response to glucose. The incretin response is attenuated in subjects with type 2 diabetes and other conditions associated with insulin resistance. Polycystic ovary syndrome (PCOS) is characterised by irregular periods and increased androgen levels. It is the most common endocrine disorder amongst young women at fertile age, and the most common cause of female infertility. Insulin resistance plays an important role in the development of the disease, and women with PCOS are at increased risk of developing tyoe 2 diabetes. the incretin hormones have not previously been investigated in women with PCOS, and the purpose of the present study was to investigate the secretion of the two most important incretin hormones Glucose-like peptide-1 (GLP-1) and Glucose dependent insulinotropic peptide (GIP) during a three hour oral glucose tolerance test.


Condition Intervention
Polycystic Ovary Syndrome
Drug: metformin

Study Type: Interventional
Study Design: Primary Purpose: Basic Science

Resource links provided by NLM:


Further study details as provided by Hvidovre University Hospital:

Enrollment: 66
Study Start Date: February 2004
Study Completion Date: May 2006
Primary Completion Date: May 2006 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: A Drug: metformin
1000 mg metformin x 2 daily during 8 months

  Eligibility

Ages Eligible for Study:   18 Years to 38 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Subjects who fulfill the Rotterdam criteria for PCOS. Age 18-38

Exclusion Criteria:

  • Other endocrine diseases or diseases known to influence glucose/insulin/fat metabolism
  • Oral contraceptive administration within three months of study start
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

No Contacts or Locations Provided
  More Information

No publications provided

Responsible Party: Incretin secretion in women with PCOS, Pernille Fog Svendsen
ClinicalTrials.gov Identifier: NCT00647023     History of Changes
Other Study ID Numbers: Incretins and PCOS
Study First Received: March 26, 2008
Last Updated: March 26, 2008
Health Authority: Denmark: The Regional Committee on Biomedical Research Ethics

Additional relevant MeSH terms:
Polycystic Ovary Syndrome
Ovarian Cysts
Cysts
Neoplasms
Ovarian Diseases
Adnexal Diseases
Genital Diseases, Female
Gonadal Disorders
Endocrine System Diseases
Metformin
Hypoglycemic Agents
Physiological Effects of Drugs
Pharmacologic Actions

ClinicalTrials.gov processed this record on July 23, 2014