Use of TREM-1 Protein to Differentiate Viral and Bacterial Pneumonias in Intubated Children
Recruitment status was Recruiting
The purpose of this study is to determine whether a protein called TREM-1 can be used to differentiate viral and bacterial pneumonias in children who are on ventilator support. We propose that the level of TREM-1 will be significantly elevated in the lung fluid of children with bacterial pneumonia and viral with co-existing bacterial pneumonia than in children with pure viral pneumonia.
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Use of a Novel Protein (sTREM-1) to Differentiate Pure Viral Lung Infection From Viral With co-Existing Bacterial Lung Infection|
- TREM-1 level in the BAL fluid of patients with pure viral pneumonia in comparison to patients with viral with co-existing bacterial pneumonia [ Time Frame: Within 48 hours of being intubated ] [ Designated as safety issue: No ]
- TREM-1 level in the BAL fluid of patients with pure bacterial pneumonia and no pneumonia [ Time Frame: Within 48 hours of intubation for TREM-1 level ] [ Designated as safety issue: No ]
- TREM-1 level in the serum of all 4 groups [ Time Frame: Within 48 hours of intubation for TREM-1 level ] [ Designated as safety issue: No ]
- Length of ventilator support, length of ICU and hospital stay [ Time Frame: Within 48 hours of intubation for TREM-1 level ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
Bronchoalveolar lavage fluid and Serum.
|Study Start Date:||November 2007|
|Estimated Study Completion Date:||June 2009|
|Estimated Primary Completion Date:||April 2009 (Final data collection date for primary outcome measure)|
Patients with pure viral pneumonia
Patients with viral pneumonia along with secondary bacterial pneumonia
Patients with significant bacterial pneumonia
Patients with congenital heart disease undergoing cardiopulmonary bypass who have no pneumonia
Most often, viruses are the cause of pneumonia in children. However, viral pneumonias are frequently associated with secondary bacterial pneumonia. It is important, though difficult, to differentiate patients who only have viral pneumonia from those who have viral pneumonia with secondary bacterial pneumonia. This will help physicians to prescribe antibiotics to only those with bacterial pneumonia and avoid antibiotic use in those with pure viral pneumonia, thus help to limit health-care cost and to decrease emergence of antibiotic resistance. In adult studies, TREM-1 has been shown to be specifically expressed in bacterial infections.
We propose that measuring TREM-1 in the bronchoalveolar lavage (BAL) fluid will help to differentiate these groups. Our hypothesis is that concentration of TREM-1 will be significantly elevated in the BAL fluid of children with bacterial pneumonia and viral with co-existing bacterial pneumonia than in children with pure viral pneumonia.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00645619
|Contact: Rangasamy K Anand, MBBS, MRCPfirstname.lastname@example.org|
|Contact: Amber Wood, RNemail@example.com|
|United States, Texas|
|Childrens Medical Center||Recruiting|
|Dallas, Texas, United States, 75235|
|Study Director:||Robert Hardy, MD||University of Texas Southwestern Medical Center|
|Study Director:||Peter Luckett, MD||University of Texas Southwestern Medical Center|