Trial record 10 of 507 for:    Chlormethine

Helium:Oxygen Noninvasive Positive Pressure Ventilation in Patients Exposed to Sulfur Mustard

This study has been completed.
Sponsor:
Information provided by:
Baqiyatallah Medical Sciences University
ClinicalTrials.gov Identifier:
NCT00642447
First received: March 19, 2008
Last updated: March 24, 2008
Last verified: March 2008
  Purpose

to assess the effect of Heliox with Noninvasive positive pressure ventilation to decrease dyspnea and improve physiologic and respiratory measures in patients with a previous exposure to Sulfur Mustard gas.


Condition Intervention Phase
Bronchiolitis
Chronic Bronchitis
Drug: helium:oxygen mixture
Phase 2
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Supportive Care
Official Title: Helium:Oxygen Versus Air:Oxygen Nonivasive Positive Pressure Ventilation in Patients Exposed to Sulfur Mustard

Resource links provided by NLM:


Further study details as provided by Baqiyatallah Medical Sciences University:

Estimated Enrollment: 23
Study Start Date: April 2007
Arms Assigned Interventions
Experimental: 1 Drug: helium:oxygen mixture

  Eligibility

Ages Eligible for Study:   38 Years to 59 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • exposure to sulfur mustard
  • worsening dyspnea during the last 10 days
  • respiratory rate of >25/min
  • arterial pH<7.35
  • PaCO2 of >50 mmHg
  • PaO2 of <50 mmHg

Exclusion Criteria:

  • recent pneumothorax (<1 month)
  • severe respiratory failure or hemodynamic instability with forthcoming intubation
  • FIO2 of <0.4
  • impaired consciousness or absence of patient cooperation
  • facial lesions precluding NIPPV
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00642447

Locations
Iran, Islamic Republic of
BMSU
Tehran, Iran, Islamic Republic of, 19945-546
Sponsors and Collaborators
Baqiyatallah Medical Sciences University
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00642447     History of Changes
Other Study ID Numbers: B12406
Study First Received: March 19, 2008
Last Updated: March 24, 2008
Health Authority: Iran: Baqiyatallah Medical Sciences University

Keywords provided by Baqiyatallah Medical Sciences University:
noninvasive ventilation
helium
oxygen
sulfur mustard
chronic bronchitis
bronchiolitis

Additional relevant MeSH terms:
Mustard Gas
Bronchiolitis
Bronchitis
Bronchitis, Chronic
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Tract Infections
Pulmonary Disease, Chronic Obstructive
Dermatologic Agents
Therapeutic Uses
Pharmacologic Actions

ClinicalTrials.gov processed this record on August 21, 2014