Fatigue is one of the most frequently observed symptoms for company workers, and oxidative stress is regarded as one of its cause. Vitamin C is a well-known antioxidant, and we seek for evidence of the efficacy of high dose vitamin C parenteral supplement on fatigue symptoms of company workers after work.
Primary Outcome Measures:
- Degree of fatigue at the point of time with visual analogue scale from 0 to 10 [ Time Frame: Before intravenous vitamin C injection and right after completing injections ] [ Designated as safety issue: No ]
Secondary Outcome Measures:
- Reactive oxygen species [ Time Frame: Before intravenous vitamin C injections, right after completing injections, and one day later ] [ Designated as safety issue: No ]
- Plasma vitamin C level [ Time Frame: Before intravenous vitamin C injections and right after completing injections ] [ Designated as safety issue: No ]
| Enrollment: |
150 |
| Study Start Date: |
March 2008 |
| Study Completion Date: |
May 2008 |
| Primary Completion Date: |
May 2008 (Final data collection date for primary outcome measure) |
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1: Experimental
Intravenous injections of 10 grams(20ml as a solution) of vitamin C with 100ml of normal saline over 30 minutes.
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Dietary Supplement: Ascorbic acid (Vitamin C)
Single intravenous injection of vitamin C 10g(20ml) with 100ml of normal saline over 30 minutes
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2: Placebo Comparator
Intravenous injections of 120ml of normal saline over 30 minutes.
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Dietary Supplement: Normal saline
Single intravenous injection of 120ml of normal saline over 30 minutes
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Previous studies dealing with vitamin C were focusing on terminal cancer patients or those with chronic fatigue syndrome. Since used drug dosage and the ways of administering vitamin C were not identical, the results were not consistent throughout those studies. This study is aimed to evaluate the efficacy of high dose vitamin C with parenteral supplement on relieving fatigue for apparently healthy volunteers.
Purpose
