Genetic Polymorphisms of Interleukin-10 and TNF-α on Outcome of HCV-Related Chronic Liver Disease

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2007 by Kaohsiung Medical University Chung-Ho Memorial Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Kaohsiung Medical University Chung-Ho Memorial Hospital
ClinicalTrials.gov Identifier:
NCT00630006
First received: February 26, 2008
Last updated: March 5, 2008
Last verified: July 2007
  Purpose

The prognosis of chronic hepatitis C virus (HCV)infeciton varies from minimal progressive disease to cirrhosis or hepatocellular carcinoma. Host genetic factors contribute to disease severity. It is known that cytokine gene (including tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) polymorphism affect disease prognosis.This study aims to assess the effect of TNF-alpha and IL-10, and their interaction,on prognosis of HCV-related chronic liver disease


Condition Intervention
Hepatitis C Virus Infection
Chronic Liver Disease
Genetic: TNF-alpha and IL-10

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Open Label

Resource links provided by NLM:


Further study details as provided by Kaohsiung Medical University Chung-Ho Memorial Hospital:

Primary Outcome Measures:
  • cytokine gene polymorphism [ Time Frame: years ]

Secondary Outcome Measures:
  • cytokine gene polymorphism on severity of disease [ Time Frame: years ]

Study Start Date: January 2007
Estimated Study Completion Date: December 2008
  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Anti-HCV-positive patients

Exclusion Criteria:

  • Anti-HCV-negative patients
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00630006

Contacts
Contact: Jen-Eing Jeng, M.D. 886-7-3121101 ext 7223 jejeng@cc.kmu.edu.tw

Locations
Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital Recruiting
Kaohsiung, Taiwan, 807
Contact: Jen-Eing Jeng, M.D.    886-7-3121101 ext 7223    jejeng @cc.kmu.edu.tw   
Principal Investigator: Jen-Eing Jeng, M.D.         
Kaohsiung Medical University Chung-Ho Memorial Hospital Recruiting
Kaohsiung, Taiwan, 807
Contact: Jen-Eing Jeng, M.D.    886-7-3121101 ext 7223    jejeng@cc.kmu.edu.tw   
Principal Investigator: Jen-Eing Jeng, M.D.         
Kaohsiung Medical University Chung-Ho Memorial Hospital Recruiting
Kaohsiung, Taiwan, 807
Contact: Jen-Eing Jeng, M.D.    886-7-3121101 ext 7223    jejeng@cc.kmu.edu.tw   
Principal Investigator: Jen-Eing Jeng, M,D,         
Sponsors and Collaborators
Kaohsiung Medical University Chung-Ho Memorial Hospital
Investigators
Principal Investigator: Jen-Eing Jeng, M.D. Assistant Professor
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00630006     History of Changes
Other Study ID Numbers: KMUH-IRB-950182
Study First Received: February 26, 2008
Last Updated: March 5, 2008
Health Authority: Taiwan: Department of Health

Additional relevant MeSH terms:
Hepatitis C
Liver Diseases
Virus Diseases
Hepatitis, Viral, Human
Flaviviridae Infections
RNA Virus Infections
Hepatitis
Digestive System Diseases

ClinicalTrials.gov processed this record on September 18, 2014