How Does Your Genetic Make-up (Profile) Influence Your Glaucoma?
Glaucoma is a group of diseases in which visual loss occurs because of damage to the optic nerve. Research has shown that certain genes may cause glaucoma in some cases. So far, research has only been able to find the genes responsible for glaucoma in a small percentage of people who have glaucoma. The purpose of this project is to study the genes in patients with and without glaucoma to find additional genes that may be responsible for causing glaucoma.
Primary Open Angle Glaucoma
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Nuclear Genetic and Mitochondrial Influences in Glaucoma|
- The investigators will quantify the spectrum of changes in mitochondrial respiration, relative mitochondrial DNA content, and oxidative stress associated with different types of glaucoma. [ Time Frame: one blood draw ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
|Study Start Date:||March 2008|
|Study Completion Date:||August 2009|
|Primary Completion Date:||August 2009 (Final data collection date for primary outcome measure)|
Primary Open Angle Glaucoma (POAG)
Controls (Normals, patients without glaucoma)
Four tubes of blood will be taken from 100 people. Of those, half will have primary open angle glaucoma (POAG) and the other half will be controls (normals), half will be caucasians and the other half will be african americans, half male and half female. All groups will have a routine ophthalmic eye exam, color vision, snellen vision, and visual field done.
|United States, Pennsylvania|
|Wills Eye Glaucoma Service|
|Philadelphia, Pennsylvania, United States, 19107|
|Principal Investigator:||George L Spaeth, MD||Wills Eye Institute|