Trial record 6 of 920 for:    coronary heart disease OR heart disease OR coronary artery disease OR atherosclerosis | Open Studies | NIH, U.S. Fed

Examining How Heart Disease Risk Factors Affect Healthy Aging (The Chicago Healthy Aging Study [CHAS])

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2009 by National Heart, Lung, and Blood Institute (NHLBI).
Recruitment status was  Recruiting
Sponsor:
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier:
NCT00626379
First received: February 27, 2008
Last updated: July 10, 2009
Last verified: July 2009
  Purpose

Heart disease is the leading cause of death in the United States and is responsible for 30% of all deaths in the United States. This study will examine how risk factors for heart disease in young and middle aged people affect people's health as they grow older.


Condition
Coronary Disease
Cardiovascular Diseases

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Low CV Risk, Ages 25-44 & CV/Non-CV Outcomes, Ages 65+

Resource links provided by NLM:


Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Primary Outcome Measures:
  • Subclinical atherosclerosis, CVD-related markers of inflammation, and levels of physical performance [ Time Frame: Measured during participant's one (baseline) study visit ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA

Whole blood, serum, white cells, and urine


Estimated Enrollment: 1500
Study Start Date: November 2007
Estimated Study Completion Date: January 2011
Estimated Primary Completion Date: March 2010 (Final data collection date for primary outcome measure)
Detailed Description:

Heart disease, including coronary heart disease (CHD) and cardiovascular disease (CVD), is a serious health problem in the United States. It is the leading cause of death in this country, and each year almost 700,000 people die from the disease. Risk factors for heart disease include high blood pressure, high cholesterol levels, tobacco use, diabetes, and history of a prior heart attack. It has been shown that young and middle aged adults with few risk factors experience a lower incidence of heart disease, lower Medicare costs, and longer lives than those with more risk factors. However, it is not known how having a low risk for heart disease at a young age affects health-related outcomes in older age. It may be possible that a low risk for developing heart disease in younger years results in healthier aging than does a higher risk. This study will examine former participants of the Chicago Heart Association (CHA) study who are now 65 to 84 years old. The purpose of this study is to determine how risk factors for heart disease in young adulthood and middle age are related to healthy aging.

This study will enroll 1500 people who participated in the CHA study from 1967 to 1973 and who are still living in the Greater Chicagoland area. Six hundred former participants who had a low risk of developing heart disease and 900 former participants who had a high risk of developing heart disease will be enrolled. Participants will attend one study visit that will include medical history interviews and questionnaires, a physical examination, blood pressure measurements, blood and urine collection, and an electrocardiogram (ECG) to measure the electrical activity of the heart. Blood samples will be collected and stored for future genetic testing. Participants will undergo physical functioning performance tests on balance, leg strength and coordination, grip strength, and endurance. They will also undergo a computed tomography chest scan to measure the amount of calcium in the arteries of the heart and ultrasound scans of the arteries in the neck to measure artery size and function.

  Eligibility

Ages Eligible for Study:   65 Years to 84 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Original participants in the Chicago Heart Association (CHA) Detection in Industry study (1967 to 1973) who still reside in the Greater Chicagoland area.

Criteria

Inclusion Criteria:

  • Participated in the CHA study
  • Lives in the Greater Chicagoland area

Exclusion Criteria:

  • Severely ill, disabled, or cognitively impaired
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00626379

Locations
United States, Illinois
Preventive Medicine Research Clinic Recruiting
Chicago, Illinois, United States, 60611
Contact: Brenna Michael    800-518-4121    brennamichael@northwestern.edu   
Contact: Frances Horn    1-800-518-4121    f-horn@northwestern.edu   
Principal Investigator: Martha L. Daviglus, MD, PhD         
Sponsors and Collaborators
Investigators
Principal Investigator: Martha L. Daviglus, MD, PhD Northwestern University Feinberg School of Medicine
  More Information

No publications provided

Responsible Party: Martha L. Daviglus, MD, PhD, Northwestern University Feinberg School of Medicine
ClinicalTrials.gov Identifier: NCT00626379     History of Changes
Other Study ID Numbers: 1379, HL081141-01A2, 0623-010
Study First Received: February 27, 2008
Last Updated: July 10, 2009
Health Authority: United States: Federal Government

Keywords provided by National Heart, Lung, and Blood Institute (NHLBI):
Coronary Heart Disease
Subclinical Atherosclerosis
CVD-Related Markers of Inflammation
Mortality

Additional relevant MeSH terms:
Cardiovascular Diseases
Coronary Artery Disease
Coronary Disease
Arterial Occlusive Diseases
Arteriosclerosis
Heart Diseases
Myocardial Ischemia
Vascular Diseases

ClinicalTrials.gov processed this record on October 23, 2014