Calcium Retention as Influenced by Dietary Components That Induce an Acid Load - Full Text View

Purpose

The impact of protein sources such as beef as part of Western diet on calcium retention remains controversial. We propose to test the hypothesis that the positive effect of high protein intake (especially from meat protein) can offset the negative effect of protein-induced net acid load on bone metabolism and the retention of body calcium. Healthy postmenopausal women recruited from the community will consume two diets differing in meat protein and acid load for 7 weeks. Calcium retention from diets will be determined using a highly sensitive measurement of whole body retention of a calcium isotope added to the diet.

Condition	Intervention
Healthy	Other: High Meat - High Potential Renal Acid Load (PRAL) diet Other: Low Protein - Low Potential Renal Acid Load (PRAL) diet

Study Type:	Interventional
Study Design:	Allocation: Randomized Endpoint Classification: Bio-availability Study Intervention Model: Crossover Assignment Masking: Open Label Primary Purpose: Prevention
Official Title:	Calcium Retention in Postmenopausal Women as Influenced by Beef and Other Dietary Components That Induce an Acid Load

Resource links provided by NLM:

MedlinePlus related topics: Calcium

Drug Information available for: Calcium Gluconate

U.S. FDA Resources

Further study details as provided by USDA Grand Forks Human Nutrition Research Center:

Primary Outcome Measures:

Calcium Absorption [ Time Frame: 18 weeks ] [ Designated as safety issue: No ]
After 3 weeks equilibration to the diet, the 2-day menu was extrinsically labeled with Calcium-47 radiotracer and retention was monitored for 28 days by whole body scintillation counting. Percent Calcium-47 absorbed was estimated from the y-intercept of the linear portion of a semilogarithmic plot of percent Calcium-47 retained vs time.

Enrollment:	22
Study Start Date:	January 2008
Study Completion Date:	May 2008
Primary Completion Date:	May 2008 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
Experimental: A Dietary Intervention: High meat and high acid load diet followed by low meat and low acid load diet	Other: High Meat - High Potential Renal Acid Load (PRAL) diet Menu high in meat protein Other: Low Protein - Low Potential Renal Acid Load (PRAL) diet Menu low in meat protein
Experimental: B Dietary Intervention: Low meat and low acid load diet followed by high meat and high acid load diet	Other: High Meat - High Potential Renal Acid Load (PRAL) diet Menu high in meat protein Other: Low Protein - Low Potential Renal Acid Load (PRAL) diet Menu low in meat protein

Eligibility

Ages Eligible for Study:	40 Years to 75 Years
Genders Eligible for Study:	Female
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Average body mass index
Normal blood work
Normal bone density

Exclusion Criteria:

Chronic disorder
Non-traumatic bone fractures

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00620763

Locations

United States, North Dakota
United States Department of Agriculture (USDA) Grand Forks Human Nutrition Research Center
Grand Forks, North Dakota, United States, 58202

Sponsors and Collaborators

USDA Beltsville Human Nutrition Research Center

Investigators

Principal Investigator:

Jay Cao, PhD

USDA Grand Forks Human Nutrition Research Center

More Information

Additional Information:

Related Info This link exits the ClinicalTrials.gov site

Publications:

Roughead ZK, Johnson LK, Lykken GI, Hunt JR. Controlled high meat diets do not affect calcium retention or indices of bone status in healthy postmenopausal women. J Nutr. 2003 Apr;133(4):1020-6.

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Cao JJ, Johnson LK, Hunt JR. A diet high in meat protein and potential renal acid load increases fractional calcium absorption and urinary calcium excretion without affecting markers of bone resorption or formation in postmenopausal women. J Nutr. 2011 Mar;141(3):391-7. Epub 2011 Jan 19.

Responsible Party:	Jay Cao, Research Nutritionist, United States Department of Agriculture (USDA) Grand Forks Human Nutrition Research Center
ClinicalTrials.gov Identifier:	NCT00620763 History of Changes
Other Study ID Numbers:	GFHNRC087, IRB-2000707-013
Study First Received:	January 18, 2008
Results First Received:	December 31, 2008
Last Updated:	August 4, 2011
Health Authority:	United States: Federal Government United States: Institutional Review Board United States: Food and Drug Administration

Keywords provided by USDA Grand Forks Human Nutrition Research Center:

Meat protein
acid load
calcium retention
postmenopausal women

Additional relevant MeSH terms:

Urinary Retention
Urination Disorders
Urologic Diseases

ClinicalTrials.gov processed this record on May 19, 2013