Genetics of Schizophrenia

The recruitment status of this study is unknown because the information has not been verified recently.
Verified February 2008 by Sheba Medical Center.
Recruitment status was  Not yet recruiting
Sponsor:
Information provided by:
Sheba Medical Center
ClinicalTrials.gov Identifier:
NCT00619437
First received: February 10, 2008
Last updated: NA
Last verified: February 2008
History: No changes posted
  Purpose

Genetic etiology in schizophrenia is widely accepted. However, many chromosomal sites were shown to characterize the families of patients with schizophrenia. This is probably due to the high genetic heterogenity of this illness. Thus, it is important to investigate the genetic factor in relatively genetically homogenous populations. Many studies have indicate that Ashkenazy Jews show relative gentic homogenity. Indeed, the genes responsible for most Mendelian disorders of Jewish peoples have been identified. The study will apply genome-wide mutation screening methods to identify candidate allells in subjects of Ashkenazi Jewish ancestry with multiplex schizophrenia.


Condition
Schizophrenia

Study Type: Observational
Study Design: Observational Model: Family-Based
Time Perspective: Prospective
Official Title: Genetics of Schizophrenia

Resource links provided by NLM:


Further study details as provided by Sheba Medical Center:

Biospecimen Retention:   Samples With DNA

Cell Lines / DNA


Estimated Enrollment: 100
Study Start Date: April 2008
Estimated Study Completion Date: December 2009
  Eligibility

Ages Eligible for Study:   18 Years to 78 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

schizophrenia

Criteria

Inclusion Criteria:

  1. Age 18+;
  2. Meet DSM-IV criteria for Schizophrenia;
  3. At least one first-degree relative who Meet DSM-IV criteria for Schizophrenia;
  4. Can sign the informed consent form.

Exclusion Criteria:

  1. Patients suffering from terminal or incurabale disease;
  2. Minors, incompetents
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00619437

Contacts
Contact: Raz Gross, MD, MPH 972 3 530 3962 razg@gertner.health.gov.il

Locations
Israel
Sheba Medical Center Not yet recruiting
Tel Hashomer, Israel
Contact: Michael Bunzel, MD         
Principal Investigator: Michael Bunzel, MD         
Sponsors and Collaborators
Sheba Medical Center
Investigators
Study Director: Michael Bunzel, MD Psychiatric ward, Sheba Medical Center
  More Information

No publications provided

Responsible Party: Raz Gross, Head, Mental Health Epidemiology, The Gertner Institute for Epidemiology
ClinicalTrials.gov Identifier: NCT00619437     History of Changes
Other Study ID Numbers: SHEBA-07-4620-RG-CTIL
Study First Received: February 10, 2008
Last Updated: February 10, 2008
Health Authority: Israel: Israeli Health Ministry Pharmaceutical Administration

Keywords provided by Sheba Medical Center:
schizophrenia
genetics
family
multiplex
haplotypes

Additional relevant MeSH terms:
Schizophrenia
Schizophrenia and Disorders with Psychotic Features
Mental Disorders

ClinicalTrials.gov processed this record on September 18, 2014