Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18: Examination of Osteosarcoma Tissue Samples From Two Family Members for Loss of Heterozygosity in the Chromosome 18 Region, Genetically Linked With Paget's Disease of Bone
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Purpose
Researchers have previously demonstrated loss of heterozygosity in a region on chromosome 18q, associated with osteogenic sarcomas in bone affected by Paget's disease. The loci used in this study are specifically described by those authors as showing loss of heterozygosity in 6 of 7 affected families.
| Condition |
|---|
|
Osteosarcoma Paget's Disease |
| Study Type: | Observational |
| Study Design: | Observational Model: Family-Based Time Perspective: Prospective |
| Official Title: | Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18: Examination of Osteosarcoma Tissue Samples From Two Family Members for Loss of Heterozygosity in the Chromosome 18 Region, Genetically Linked With Paget's Disease of Bone |
Once a specimen is obtained DNA will be isolated for paraffin-embedded tissue and peripheral blood. Osteosarcoma samples from paraffin embedded, formalin-fixed post-surgical tissue samples will be obtained for the proband and father. Matched normal spamples will be obtained from these individuals as adjacent normal tissue from the post-surgical specimens
| Estimated Enrollment: | 9 |
| Study Start Date: | April 2002 |
| Estimated Primary Completion Date: | December 2009 (Final data collection date for primary outcome measure) |
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
This is a familial study therefore the only inclusion/exclusion criteria would be that subjects must be a blood relative and over the age of 18. The subjects are proband and father along with unaffected blood relatives. Their peripheral blood will act as a control and provide information to delineate the inheritance from the father, as seen in the son.
Inclusion Criteria:
- This is a familial study therefore the only inclusion/exclusion criteria would be that subjects must be a blood relative and over the age of 18.
- The subjects are proband and father along with unaffected blood relatives. Their peripheral blood will act as a control and provide information to delineate the inheritance from the father, as seen in the son.
Exclusion Criteria:
- Not part of the family
Contacts and Locations| United States, New York | |
| SUNY Upstate Medical University | |
| Syracuse, New York, United States, 13202 | |
| Principal Investigator: | Timothy A Damron, MD | State University of New York - Upstate Medical University |
More Information
No publications provided
| Responsible Party: | Timothy A Damron, MD, Orthopedic Surgery |
| ClinicalTrials.gov Identifier: | NCT00615628 History of Changes |
| Other Study ID Numbers: | Osteosarcoma & Paget's Disease, IRB #4168 |
| Study First Received: | February 1, 2008 |
| Last Updated: | June 25, 2009 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by State University of New York - Upstate Medical University:
|
Inheritance of Osteosarcoma & Paget's Disease through Chromosome 18 |
Additional relevant MeSH terms:
|
Bone Diseases Osteitis Deformans Osteosarcoma Musculoskeletal Diseases Neoplasms, Bone Tissue |
Neoplasms, Connective Tissue Neoplasms, Connective and Soft Tissue Neoplasms by Histologic Type Neoplasms Sarcoma |
ClinicalTrials.gov processed this record on May 19, 2013