A Pilot Evaluation of the Impact of Alcohol Use on Airway Inflammation and Mechanics in Asthmatics (AIM Asthma)
Since 1980, the number of people in the United States diagnosed with asthma has increased dramatically. Studying what causes and triggers asthma is an important part of understanding and subsequently managing this disease. Although some have suggested that alcohol consumption may affect asthma, little is known about how consistent alcohol use affects the amount of inflammation present in the lungs and whether consistent alcohol use makes the airways more narrow and stiff.
Participation in this study involves 2 visits in order to complete questionnaires, various pulmonary function tests, as well as the collection of blood, urine, and exhaled breath condensate specimens.
This study includes optional genetic and bronchoscopy substudies.
|Study Design:||Time Perspective: Cross-Sectional|
- Measurements of airway oxidative stress (increased GSSG/GS, and RNS/NO ratios and higher exhaled 8-isoprostanes levels) [ Time Frame: single timepoint ] [ Designated as safety issue: No ]
- Measurements of lung function (spirometry, response to methacholine challenge, and impulse oscillometry). [ Time Frame: single timepoint ] [ Designated as safety issue: No ]
- Asthma symptoms and control through standard asthma questionnaires [ Time Frame: single timepoint ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Blood, urine, and exhaled breath condensate
|Study Start Date:||January 2007|
Asthmatics who consume 3 or more alcoholic beverages per day (on average)
Asthmatics who do not drink alcohol or consume less than or equal to 2 alcoholic beverages per month