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Brain Imaging of Psychotherapy for Depression

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Gabriel Dichter, University of North Carolina, Chapel Hill
ClinicalTrials.gov Identifier:
NCT00609453
First received: January 24, 2008
Last updated: October 5, 2012
Last verified: October 2012
History of Changes
  Purpose

The goal of the proposed research is to examine the neural correlates of depressive symptom reduction in individuals with major depressive disorder using functional magnetic resonance imaging (fMRI), and to compare results to those obtained from a nondepressed control group.


Condition Intervention
Major Depressive Disorder
 Behavioral: Brief Behavioral Activation Treatment for Depression

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Official Title: Brain Imaging of Psychotherapy for Depression (Includes, "Reward System Recovery Following Behavioral Activation Therapy in Depression")

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University of North Carolina, Chapel Hill:

Primary Outcome Measures:
  • Hamilton Depression Inventory [ Time Frame: three times over 12 weeks ] [ Designated as safety issue: No ]
  • Functional Magnetic Resonance Imaging [ Time Frame: twice in 12 weeks ] [ Designated as safety issue: No ]

Enrollment: 27
Study Start Date: October 2006
Study Completion Date: January 2008
Primary Completion Date: January 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
Individuals with major depressive disorder receiving therapy
 Behavioral: Brief Behavioral Activation Treatment for Depression
Weekly individual therapy sessions

  Eligibility

Ages Eligible for Study:   21 Years to 55 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • For group 1: Diagnosis of current depression and no other current Axis I psychiatric disorder
  • For group 1: Hamilton Depression Rating Scale score of 15 or greater

Exclusion Criteria:

  • A history of serious head injury or neurological disease or psychosis
  • Current use of psychoactive medications
  • Factors that could affect MRI safety including current or planned pregnancy
  • For group 2: current Axis I psychiatric disorder, as assessed by structured clinical interview
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00609453

Locations
United States, North Carolina
Duke-UNC Brain Imaging and Analysis Center
Durham, North Carolina, United States, 27710
Sponsors and Collaborators
University of North Carolina, Chapel Hill
Investigators
Principal Investigator: Gabriel S Dichter, PhD University of North Carolina, Chapel Hill
  More Information

No publications provided

Responsible Party: Gabriel Dichter, Associate Professor of Psychiatry, University of North Carolina, Chapel Hill
ClinicalTrials.gov Identifier: NCT00609453     History of Changes
Other Study ID Numbers: 05-2605, NIMH R03 MH078145
Study First Received: January 24, 2008
Last Updated: October 5, 2012
Health Authority: United States: Institutional Review Board

Keywords provided by University of North Carolina, Chapel Hill:
Control participants

Additional relevant MeSH terms:
Depression
Depressive Disorder
Depressive Disorder, Major
 Behavioral Symptoms
Mood Disorders
Mental Disorders

ClinicalTrials.gov processed this record on May 19, 2013