Day 3 Embryo Cryopreservation: Metabolic and Viability Analysis

This study has been completed.
Sponsor:
Information provided by:
V.K.V. American Hospital, Istanbul
ClinicalTrials.gov Identifier:
NCT00608010
First received: January 22, 2008
Last updated: February 5, 2008
Last verified: January 2008
  Purpose

Embryo preservation through freezing plays a significant role in human assisted reproduction. It provides an opportunity for patients to have more than one attempt following an ovarian stimulation cycle, thereby decreasing the exposure of patients to exogenous gonadotrophins and improving cumulative pregnancy rates. The purpose of this study is to compare effectiveness of two different freezing methods.


Condition Intervention
Fertilization in Vitro
Preservation of Supernumerary Embryos
Procedure: Vitrification
Procedure: Slow freezing

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Day 3 Embryo Cryopreservation: Metabolic and Viability Analysis

Further study details as provided by V.K.V. American Hospital, Istanbul:

Primary Outcome Measures:
  • Blastocyst development rate [ Time Frame: 3 days after thawing ] [ Designated as safety issue: No ]

Enrollment: 186
Study Start Date: October 2006
Primary Completion Date: January 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
Vitrification
Procedure: Vitrification
Embryos were vitrified according to a previously described technique
Active Comparator: 2
Slow freezing
Procedure: Slow freezing
Embryos were frozen with slow freezing technique

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • ICSI with own gametes
  • Couples who did not wish to cryopreserve their excess embryos for possible transfer in a future cyle
  • Donating excess embryos for research purposes

Exclusion Criteria:

  • Embryos derived from surgically retrieved spermatozoa
  • Blastocysts
  • Embryos of low quality (Grade 3 or 4 according to Hardarson)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00608010

Locations
Turkey
American Hospital of Istanbul
Istanbul, Turkey, 34365
Sponsors and Collaborators
V.K.V. American Hospital, Istanbul
Investigators
Principal Investigator: Basak Balaban, BSc American Hospital of Istanbul
  More Information

No publications provided by V.K.V. American Hospital, Istanbul

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Basak Balaban, Chief Embryologist, American Hospital of Istanbul
ClinicalTrials.gov Identifier: NCT00608010     History of Changes
Other Study ID Numbers: AH-ART-06/13
Study First Received: January 22, 2008
Last Updated: February 5, 2008
Health Authority: Turkey: Ministry of Health

Keywords provided by V.K.V. American Hospital, Istanbul:
Preservation of supernumerary embryos in an IVF program

ClinicalTrials.gov processed this record on October 21, 2014