Effect of Nutrition on Muscle Protein Synthesis

This study has been completed.
Information provided by:
Maastricht University Medical Center
ClinicalTrials.gov Identifier:
First received: January 17, 2008
Last updated: March 4, 2009
Last verified: March 2009

The present proposal is designed to examine the effect of carbohydrate and protein co-ingestion on muscle protein synthesis during endurance type exercise activities. We hypothesize that muscle protein synthesis is higher when protein is co-ingested during exercise.

Condition Intervention
Dietary Supplement: carbohydrate and protein

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Basic Science
Official Title: The Effect of Carbohydrate and Protein Intake on Muscle Protein Synthesis During Endurance Exercise

Resource links provided by NLM:

Further study details as provided by Maastricht University Medical Center:

Primary Outcome Measures:
  • Differences in muscle protein synthesis rates between carbohydrate and carbohydrate + protein. [ Time Frame: 1 day ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Difference in whole-body protein synthesis and breakdown between carbohydrate and carbohydrate plus protein. [ Time Frame: 1 day ] [ Designated as safety issue: No ]

Enrollment: 12
Study Start Date: August 2008
Study Completion Date: February 2009
Primary Completion Date: February 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1 Dietary Supplement: carbohydrate and protein
The intake of carbohydrate and protein during endurance type exercise


Ages Eligible for Study:   18 Years to 28 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • recreationally endurance trained

Exclusion Criteria:

  • BMI > 25 kg/m2
  • Not physically active
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00604929

Sponsors and Collaborators
Maastricht University Medical Center
Principal Investigator: L van Loon, PhD Maastricht University
  More Information

No publications provided

Responsible Party: L.J.C. van Loon, PhD, Maastricht university
ClinicalTrials.gov Identifier: NCT00604929     History of Changes
Other Study ID Numbers: MEC 83017
Study First Received: January 17, 2008
Last Updated: March 4, 2009
Health Authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Keywords provided by Maastricht University Medical Center:
muscle protein synthesis
whole-body protein breakdown

ClinicalTrials.gov processed this record on April 20, 2014