Hippocampal Radiation Exposure and Memory
Recruitment status was Recruiting
Neurocognitive impairment as a result of gamma knife radiosurgery has not been well studied and is poorly understood. Radiosurgery to the base of skull for the treatment of benign and malignant disorders may consequently impair memory function. There is a need to evaluate changes in memory function that may be associated with such exposures.
In this pilot study, we will investigate changes in hippocampal-dependent memory function in 10 patients receiving a low SRS dose to the hippocampus. We will also investigate such changes in a no-dose control group and a high-dose control group. This study will provide preliminary estimates of variance in memory changes associated with radiation exposure, and will then permit us to design future studies with the appropriate sample size justification.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Hippocampal Radiation Exposure and Memory: A Pilot Study|
|Study Start Date:||September 2007|
(Experimental group): Receiving > 2 Gy SRS to left hippocampus (n=10)
(Low-dose control group): Receiving < 0.5 Gy SRS to left hippocampus (n=10)
(High-dose control group): Receiving whole brain PCI (n=10)
|Contact: Heather Sharpe, B.Sc.||firstname.lastname@example.org|
|Joey & Toby Tanenbaum Gamma Knife Centre, Toronto Western Hospital||Recruiting|
|Toronto, Ontario, Canada, M5T 2S8|
|Principal Investigator: Cynthia Menard, Docorate|
|Sub-Investigator: Iwa Kong|