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Exploring the Role of 3T MRI in Gamma Knife Radiosurgery

This study is currently recruiting participants.
Verified by University Health Network, Toronto, September 2007

Sponsored by: University Health Network, Toronto
Information provided by: University Health Network, Toronto
ClinicalTrials.gov Identifier: NCT00602992
  Purpose

Gamma Knife radiosurgery is a non-invasive technique for the delivery of a single, high dose of radiation to an intra-cranial target. MRI has an established and central role in the treatment planning process and assessment of response to intracranial radiosurgery. Increasing the field strength of MRI from 1.5T to 3T promises to improve the signal, and in turn the quality of images. However, the technology also introduces new limitations, and the role and safety of 3T MRI in the management of patients receiving radiosurgery has not yet been reported. In this pilot study, we will explore the spatial integrity, and incremental image-guidance utility of 3T MRI in patients receiving radiosurgery. The preliminary data acquired in this study will be instrumental to the judicious design and conduct of subsequent definitive clinical trials. Up to fifty patients will be enrolled in this study.


Condition
Trigeminal Neuralgia
Acoustic Neuroma
Brain Metastases

Genetics Home Reference related topics:   neurofibromatosis type 2   

MedlinePlus related topics:   Trigeminal Neuralgia   

U.S. FDA Resources

Study Type:   Observational
Study Design:   Cohort, Cross-Sectional
Official Title:   Exploring the Role of 3T MRI in Gamma Knife Radiosurgery: A Pilot Study

Further study details as provided by University Health Network, Toronto:

Biospecimen Retention:   None Retained

Biospecimen Description:

Estimated Enrollment:   50
Study Start Date:   August 2006

  Eligibility
Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample

Study Population

Patients who have consented to Gamma Knife radiosurgery.


Criteria

Inclusion Criteria:

  • Patients planned to receive Gamma Knife radiosurgery will be eligible for enrollment on this study.

Exclusion Criteria:

  • Age<18
  • Contra-indications to 3T MRI, such as implanted metal devices or shrapnel.
  Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00602992

Contacts
Contact: Heather A Sharpe, B.Sc.     416-946-4501 ext 3427     heather.sharpe@uhn.on.ca    

Locations
Canada, Ontario
Toronto Western Hospital     Recruiting
      Toronto, Ontario, Canada, M5T 2S8
      Contact: Heather Sharpe, B. Sc.     416-946-4501 ext 3427     heather.sharpe@uhn.on.ca    
      Principal Investigator: Cynthia Menard, MD            

Sponsors and Collaborators
University Health Network, Toronto

Investigators
Principal Investigator:     Cynthia Menard, MD     University Health Network, Toronto    
  More Information

Responsible Party:   University Health Network ( Dr. Cynthia Menard )
Study ID Numbers:   06-0427-CE
First Received:   September 19, 2007
Last Updated:   January 26, 2008
ClinicalTrials.gov Identifier:   NCT00602992
Health Authority:   Canada: Health Canada

Keywords provided by University Health Network, Toronto:
3T MRI  
Gamma Knife Radiosurgery  

Study placed in the following topic categories:
Vestibulocochlear Nerve Diseases
Otorhinolaryngologic Neoplasms
Otorhinolaryngologic Diseases
Neuroma, Acoustic
Neuralgia
Trigeminal neuralgia
Neurilemmoma
Pain
Acoustic neuroma
Ear Diseases
Neuroendocrine Tumors
Signs and Symptoms
Neuroectodermal Tumors
Neuromuscular Diseases
Neoplasms, Germ Cell and Embryonal
Peripheral Nervous System Diseases
Neoplasm Metastasis
Neuroepithelioma
Neurologic Manifestations
Neuroma
Nervous System Neoplasms
Nerve Sheath Neoplasms
Trigeminal Neuralgia

Additional relevant MeSH terms:
Neoplasms
Neoplastic Processes
Neoplasms by Site
Neoplasms by Histologic Type
Pathologic Processes
Retrocochlear Diseases
Neoplasms, Nerve Tissue
Nervous System Diseases
Cranial Nerve Neoplasms
Trigeminal Nerve Diseases
Cranial Nerve Diseases
Peripheral Nervous System Neoplasms

ClinicalTrials.gov processed this record on September 05, 2008




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