Low-Dose Chest Computed Tomography Screening for Lung Cancer in Survivors of Hodgkin's Disease
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Purpose
This research study is being done because patients with a history of chest radiation treatment for Hodgkin's disease have been shown to be at increased risk for developing lung cancer a number of years out from treatment. The risk appears to be further increased among patients with a smoking history. Currently, the practice is to recommend annual low-dose chest CT scans in survivors of Hodgkin's disease who have received prior chest radiation treatment and who have at least a moderate smoking history. In this study, the CT scans will be read and interpreted by the study radiologist, and the results recorded in a consistent manner.
| Condition | Intervention |
|---|---|
|
Lung Cancer |
Procedure: chest computed tomography scan |
| Study Type: | Observational |
| Study Design: | Observational Model: Case-Only Time Perspective: Prospective |
| Official Title: | Low-Dose Chest Computed Tomography Screening for Lung Cancer in Survivors of Hodgkin's Disease |
- To prospectively collect data on chest CT screening for patients at increase lung-cancer risk after Hodgkin's disease. [ Time Frame: 3 years ] [ Designated as safety issue: No ]
| Enrollment: | 39 |
| Study Start Date: | November 2006 |
| Primary Completion Date: | December 2010 (Final data collection date for primary outcome measure) |
-
Procedure: chest computed tomography scan
- Participants will undergo a chest computed tomography (CT) scan once a year for a 3-year period.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Survivors of Hodgkin's disease seen for follow-up at the Brigham and Women's Hosptial Department of Radiation Oncology, the Lance Armstrong Adult Survivorship Clinic and the David B. Perini Jr. Childhood Cancer Survivor Clinic at the Dana Farber-Cancer Institute
Inclusion Criteria:
- 5 years or longer from initial Hodgkin's disease diagnosis
- Current age 18 or older
- Received mediastinal irradiation and/or alkylating-agent based chemotherapy
- Smoking history of 10-pack years or more, or current smoker
- Pre-approval from the participant's insurance company for the CT study
Exclusion Criteria:
- Patients with a history of lung cancer
- Currently receiving treatment for another cancer diagnosis
- Known diagnosis of any metastatic cancer
- Pregnant women
Contacts and Locations| United States, Massachusetts | |
| Brigham and Women's Hospital | |
| Boston, Massachusetts, United States | |
| Dana-Farber Cancer Institute | |
| Boston, Massachusetts, United States, 02115 | |
| Principal Investigator: | Andrea K. Ng, MD | Dana-Farber Cancer Institute/Brigham and Women's Hospital |
More Information
No publications provided
| Responsible Party: | Andrea K. Ng, MD, Radiation Oncologist, Dana-Farber Cancer Institute |
| ClinicalTrials.gov Identifier: | NCT00601146 History of Changes |
| Other Study ID Numbers: | 06-122 |
| Study First Received: | January 15, 2008 |
| Last Updated: | August 13, 2012 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by Dana-Farber Cancer Institute:
|
Hodgkin's disease CT scan |
Additional relevant MeSH terms:
|
Hodgkin Disease Lymphoproliferative Disorders Lymphatic Diseases Immunoproliferative Disorders Immune System Diseases Lung Diseases Respiratory Tract Diseases |
Lung Neoplasms Lymphoma Neoplasms by Histologic Type Neoplasms Respiratory Tract Neoplasms Thoracic Neoplasms Neoplasms by Site |
ClinicalTrials.gov processed this record on May 19, 2013