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Propofol Sedation Study (SPIN)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Steven Logan, Scottsdale Healthcare
ClinicalTrials.gov Identifier:
NCT00597740
First received: January 9, 2008
Last updated: December 2, 2013
Last verified: December 2013
  Purpose

Purpose of Protocol: The purpose of this study will be to compare the clinical utility of Propofol sedation with and without the use of the ICU Sedation Protocol. Patients will be treated according to the attending/consulting preference. No attempt will be made to influence the patient's routine care and management. The study will compare the average hourly infusion rates for the Propofol administration, as well as obtain the nursing staffs evaluation regarding the ease of neurological assessment during each 12 hour shift


Condition
Anesthesia

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Clinical Utility of Propofol Sedations Without and With a Formal "ICU Sedation Protocol" in Intubated Neurotrauma Patients

Resource links provided by NLM:


Further study details as provided by Scottsdale Healthcare:

Enrollment: 57
Study Start Date: December 2007
Study Completion Date: December 2013
Primary Completion Date: September 2010 (Final data collection date for primary outcome measure)
Detailed Description:

Study Objectives and Design: Propofol is a short-acting sedative that is easily titratable, and is approved for use in ventilated patients. The clinical usefulness of continuous intravenous infusion of Propofol has been demonstrated in the management of ventilated ICU patients. In addition, its short duration of action permits repeated neurological assessments to be carried out in patients with neurotrauma.

Despite these benefits, Propofol is not without some drawbacks, including a lack of analgesic effects, dose dependent lowering of blood pressure, and significant expense. To address these issues, the PI developed an ICU Sedation Protocol that combines a titrated continuous infusion of intravenous morphine sulfate with the Propofol infusion to achieve the desired level of sedation. This ICU Sedation Protocol has been approved for use at Scottsdale Healthcare since 2004, and printed copies are available at all ICU nursing stations on the Osborn campus.

At the present time, the ICU Sedation Protocol is used regularly by only two of the five neurosurgeons that care for the neurotrauma patients at the Osborn campus. The remaining three neurosurgeons prefer to use a continuous Propofol infusion with intermittent doses of intravenous morphine sulfate.

The purpose of the study will be to compare the clinical utility of Propofol sedation with and without the use of the ICU Sedation Protocol. Patients will be treated according to the attending neurosurgeons preference. No attempt will be made to influence the patient's routine care and management. The study will compare the average hourly infusion rates for Propofol administration, as well as evaluating the difficulty of neurological assessment, and the ease of weaning to extubation.

This is a prospective, non-randomized, open treatment protocol open to ICU patients at Scottsdale Healthcare Osborn. Only patients with neurotrauma that require intubation will be eligible for enrollment. Patients will be treated according to the consulting neurosurgeons preference. No attempt will be made to influence the patient's routine care and management, as already stated. The choice of sedation type and use of the ICU Sedation Protocol will be at the consulting neurosurgeons discretion.

Involvement in the protocol will cease when continuous intravenous sedation is discontinued for more than 24 hours, the patient is extubated or undergoes tracheostomy, or is transferred from the ICU.

  Eligibility

Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Neurotrauma ICU patients brought to our level one trauma facility requiring intubation.

Criteria

Inclusion Criteria:

  • Ages 18-80 (inclusive)
  • Admitted to trauma service
  • Intubated and on respiratory support
  • Neurosurgical consultation for closed head injury and/or spinal trauma
  • Informed consent from next of kin or POA

Exclusion Criteria:

  • Patients less than 18 or more than 80 years of age
  • GCS of 3 with bilaterally fixed and dilated pupils
  • Penetrating head trauma (e.g., gun shot wounds, nail gun injuries, etc.)
  • Pregnant women
  • Mentally impaired.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00597740

Locations
United States, Arizona
Scottsdale Healthcare Osborn
Scottsdale, Arizona, United States, 85251
Sponsors and Collaborators
Scottsdale Healthcare
Investigators
Principal Investigator: Joseph Zabramski, MD Scottsdale Healthcare Osborn - Neurosurgery
  More Information

No publications provided

Responsible Party: Steven Logan, Research Compliance Administrator, Scottsdale Healthcare
ClinicalTrials.gov Identifier: NCT00597740     History of Changes
Other Study ID Numbers: 2007-106
Study First Received: January 9, 2008
Last Updated: December 2, 2013
Health Authority: United States: Institutional Review Board

ClinicalTrials.gov processed this record on November 20, 2014