Hyperbaric Oxygen Therapy and SPECT Brain Imaging in Carbon Monoxide Poisoning

This study is currently recruiting participants. (see Contacts and Locations)
Verified March 2014 by Louisiana State University Health Sciences Center in New Orleans
Sponsor:
Collaborator:
Harch Hyperbaric Research Foundation
Information provided by (Responsible Party):
Paul G. Harch, M.D., Louisiana State University Health Sciences Center in New Orleans
ClinicalTrials.gov Identifier:
NCT00596180
First received: January 4, 2008
Last updated: March 30, 2014
Last verified: March 2014
  Purpose

That SPECT brain imaging tracks and is consistent with clinical history and physical exam as well as cognitive testing.


Condition Intervention Phase
Neuropsychiatric Sequelae of Carbon Monoxide Poisoning
Drug: HBOT
Phase 1

Study Type: Interventional
Study Design: Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Hyperbaric Oxygen Therapy and SPECT Brain Imaging in Carbon Monoxide Poisoning

Resource links provided by NLM:


Further study details as provided by Louisiana State University Health Sciences Center in New Orleans:

Primary Outcome Measures:
  • SPECT brain imaging [ Time Frame: after completion of HBOT ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • clinical history and physical exam [ Time Frame: after completion of HBOT ] [ Designated as safety issue: No ]
  • Neuropsychological testing [ Time Frame: After the final HBOT ] [ Designated as safety issue: Yes ]
    Neuropsychological testing performed after the final HBOT in those who had neuropsychological testing before HBOT


Estimated Enrollment: 40
Study Start Date: January 2007
Estimated Study Completion Date: December 2015
Estimated Primary Completion Date: December 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
HBOT
Drug: HBOT
total body exposure to greater than atmospheric pressure oxygen

Detailed Description:

The study is a retrospective review of the PI's experience using SPECT brain imaging and hyperbaric oxygen therapy in the diagnosis and treatment of non-acute phases of carbon monoxide poisoning. The purpose is to see if the SPECT brain imaging is consistent with the clinical condition and cognitive testing on the patients.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Adults and children with non-acute carbon monoxide poisoning who underwent SPECT brain imaging as part of their evaluation and treatment

Exclusion Criteria:

  • None.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00596180

Contacts
Contact: Paul G Harch, M.D. 504-309-4948 paulharchmd@gmail.com

Locations
United States, Louisiana
Family Physicians Center Recruiting
Marrero, Louisiana, United States, 70072
Contact: Paul G Harch, M.D.    504-309-4948    paulharchmd@gmail.com   
Principal Investigator: Paul G Harch, M.D.         
Sponsors and Collaborators
Paul G. Harch, M.D.
Harch Hyperbaric Research Foundation
Investigators
Principal Investigator: Paul G Harch, M.D. LSU School of Medicine
  More Information

No publications provided

Responsible Party: Paul G. Harch, M.D., Clinical Professor of Medicine, Louisiana State University Health Sciences Center in New Orleans
ClinicalTrials.gov Identifier: NCT00596180     History of Changes
Other Study ID Numbers: LSU IRB #6626
Study First Received: January 4, 2008
Last Updated: March 30, 2014
Health Authority: United States: Institutional Review Board

Keywords provided by Louisiana State University Health Sciences Center in New Orleans:
carbon monoxide poisoning
brain injury

Additional relevant MeSH terms:
Carbon Monoxide Poisoning
Poisoning
Gas Poisoning
Substance-Related Disorders
Carbon Monoxide
Antimetabolites
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions

ClinicalTrials.gov processed this record on July 29, 2014