Development of a Model to Evaluate Regenerative Endodontic Techniques Using Extract Human Teeth
Millions of teeth are saved each year by root canal therapy. Although current treatment modalities offer high levels of success for many conditions, an ideal form of therapy might consist of regenerative approaches in which diseased or necrotic pulp tissues are removed and replaced with healthy pulp tissue in order to revitalize teeth.
Dental Pulp Regeneration
Dental Pulp Diseases
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Development of a Model to Evaluate Regenerative Endodontic Techniques|
extracted teeth 10ml of blood for DNA banking
|Study Start Date:||February 2007|
|Study Completion Date:||September 2012|
|Primary Completion Date:||September 2012 (Final data collection date for primary outcome measure)|
The long term goal of this research project is to develop a method to regenerate dental pulp-like tissue as an alternative method to conventional root canal treatment. The objective of this study is to identify the methods necessary to regenerate dental pulp-like tissue in human teeth. We will collect small (~4X4mm) pieces of oral mucosa that are normally removed during surgical tooth extractions, isolate human postnatal progenitor/stem cells and, using an in vitro cell culture system, combined isolated cells with various scaffolds and test compounds to determine optimal conditions to differentiate pulp-like tissue (eg, odontoblasts, fibroblasts, endothelium, etc) grown in segments of human roots.
|United States, Texas|
|The University of Texas Health Science Center at San Antonio|
|San Antonio, Texas, United States, 78229|
|Principal Investigator:||Kenneth M Hargreaves, DDS, PhD||University of Texas Health Science Center at San Antonio|