Barrett's Esophagus Related Neoplasia (BERN) Project
- The use of high resolution endoscopy (HRE), narrow band imaging (NBI) and chromoendoscopy increases the detection rates of Barrett's esophagus (BE) and early neoplasia.
- Endoscopic mucosal resection (EMR) will improve the accuracy for detection of dysplasia/early neoplasia.
Specific Aim 1 - To create a video-atlas of non-dysplastic and dysplastic/early neoplastic lesions in patients with BE. This will be used for training purposes and to assess learning curve associated with these new technologies.
Specific Aim 2 - To create a standardized classification system for the mucosal and vascular patterns observed in patients with BE.
Specific Aim 3 - To determine the interobserver agreement using the video-atlas for the mucosal and vascular patterns classification agreed upon.
Specific Aim 4 - To determine the endoscopic detection rate of esophageal cancer or precancerous lesions removed during endoscopy.
Specific Aim 5 - To determine the pathologic and clinical outcomes of patients undergoing EMR/ablation; including morbidity, mortality and complications of the procedure.
Results to date (June 2008) : this study is active and open to enrollment. Currently 26 patients have enrolled in this study at the Kansas City VA medical center. In order to participate, patients must be eligible for care at the KCVA hospital.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Endoscopic Detection of Early Neoplasia in Patients With Barrett's Esophagus|
|Study Start Date:||May 2007|
|Estimated Study Completion Date:||December 2015|
|Estimated Primary Completion Date:||December 2015 (Final data collection date for primary outcome measure)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00590239
|Contact: April Higbee, BN||8168614700 ext 57456||April.Higbee@va.gov|
|United States, Missouri|
|Kansas city VA Medical center||Recruiting|
|Kansas city, Missouri, United States, 64128|
|Contact: April Higbee, RN 816-861-4700 ext 57456 email@example.com|
|Sub-Investigator: Amit Rastogi, MD|
|Sub-Investigator: Ajay Bansal, MD|
|Principal Investigator: Prateek Sharma, MD|
|Principal Investigator:||Prateek Sharma, MD||Kansas city VA Medical Center|