Identification of New Colorectal Cancer Genes
The purpose of this study is to define new genes for family risks of developing colon cancer.
|Study Design:||Observational Model: Family-Based
Time Perspective: Prospective
|Official Title:||Identification of New Colorectal Cancer Genes|
- Evidence of mutations in selected candidate genes [ Time Frame: 10 years 10 months ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Blood Tissue (tumor)
|Study Start Date:||February 1998|
|Estimated Study Completion Date:||December 2013|
|Estimated Primary Completion Date:||December 2013 (Final data collection date for primary outcome measure)|
Colorectal cancer is one of the most significant causes of cancer morbidity and mortality in the United States. In 1997, approximately 130,000 men and woman were diagnosed with colorectal cancer (fourth most common cancer site) and approximately 55,000 died of this disease (second most common cause of cancer deaths); (Cancer Facts & Figures, 1997).
Genetic factors clearly contribute to the etiology of colorectal cancer. Because there is evidence to suggest genetically determined susceptibility to colorectal cancer exists in a proportion of newly diagnosed cases each year, we are conducting a study to identify new genes that are associated with an increased susceptibility to familial colorectal cancer by analysis of families with a clustering of colorectal cancers.
|United States, New York|
|Memorial Sloan-Kettering Cancer Center|
|New York, New York, United States, 10065|
|Principal Investigator:||Kenneth Offit, MD||Memorial Sloan-Kettering Cancer Center|