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| Sponsor: | University of California, Davis |
|---|---|
| Information provided by: | University of California, Davis |
| ClinicalTrials.gov Identifier: | NCT00580255 |
Purpose
It is hypothesized that elevated BNP level correlate with an elevated thoracic impedance/fluid index as measured separately by CRT-D devices and external impedance cardiography. Ultimately, it is also hypothesized that both BNP and thoracic impedance/fluid index measurements are predictive of atrial and ventricular arrhythmias.
| Condition |
|---|
|
Heart Failure Arrhythmias |
| Study Type: | Observational |
| Study Design: | Cohort, Prospective |
| Official Title: | Does Elevated Brain Natriuretic Peptide (BNP) Reflect Changes in Thoracic Impedance Levels and Affect Occurrence of Atrial and Ventricular Arrhythmias? |
Teaspoon of blood drawn for testing of BNP levels.
| Estimated Enrollment: | 25 |
| Study Start Date: | October 2006 |
| Estimated Study Completion Date: | October 2009 |
| Estimated Primary Completion Date: | October 2009 (Final data collection date for primary outcome measure) |
The primary aim of this study:
Eligibility| Ages Eligible for Study: | 18 Years to 85 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Potential candidates with criteria for implantable cardiac resynchronization therapy who have or will undergo implantation of a Medtronic CRT-D device with thoracic impedance measurement capabilities, will be eligible to enter the study if they meet all of the inclusion criteria and none of the exclusion criteria. Patients will be enrolled in the study either at the time of device implantation or if they have already undergone device implantation will be enrolled at next routine outpatient clinic visit.
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: Melissa Mangum, BS | 916-734-7199 | melissa.mangum@ucdmc.ucdavis.edu |
| Contact: Uma Srivatsa, MD | 916-734-3764 | uma.srivatsa@ucdmc.ucdavis.edu |
| United States, California | |
| U C Davis Medical Center | Recruiting |
| Sacramento, California, United States, 95817 | |
| Principal Investigator: | Uma Drivatsa, MD | U C Davis Medical Center |
More Information
| Responsible Party: | U C Davis Medical Center ( Uma Srivatsa, MD ) |
| Study ID Numbers: | 200614766 |
| Study First Received: | December 20, 2007 |
| Last Updated: | June 4, 2008 |
| ClinicalTrials.gov Identifier: | NCT00580255 History of Changes |
| Health Authority: | United States: Institutional Review Board |
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CHF CRT Atrial Arrhythmias |
Ventricular Arrhythmias BioZ Optivol |
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Natriuretic Peptide, Brain Heart Failure Pathologic Processes Heart Diseases Natriuretic Agents Therapeutic Uses |
Physiological Effects of Drugs Cardiovascular Diseases Cardiovascular Agents Pharmacologic Actions Arrhythmias, Cardiac |