Ascertainment of Saliva or Blood Samples For Genetic Epidemiology Studies of Cancer and Aging

This study is currently recruiting participants. (see Contacts and Locations)
Verified February 2014 by Memorial Sloan-Kettering Cancer Center
Sponsor:
Collaborators:
Susan G. Komen Breast Cancer Foundation
Beth Abraham
Gurwin Jewish Nursing & Rehabilitation Center
Hebrew Home for the Aged
Jewish Home and Hospital Lifecare System
Margaret Tietz Center
Metropolitan Jewish Health System
Northern Services Group
Parker Jewish Institute
Lenox Hill Neighborhood House
JASA at Temple Emanuel of Parkchester Senior Center
Van Cortlandt Village Senior Center
Information provided by (Responsible Party):
Memorial Sloan-Kettering Cancer Center
ClinicalTrials.gov Identifier:
NCT00579618
First received: December 20, 2007
Last updated: February 5, 2014
Last verified: February 2014
  Purpose

The purpose of this study is to help us learn more about the roles of genes in cancers. Genes are short pieces of DNA which determine the inherited characteristics that distinguish one individual from another. This study will look at how some genes might raise or lower the chance some people may develop cancer. The sample collection will help generate the materials needed for this study.


Condition Intervention
Non-cancer Affected Volunteers
Other: Saliva or Blood samples

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Ascertainment of Saliva or Blood Samples For Genetic Epidemiology Studies of Cancer and Aging

Resource links provided by NLM:


Further study details as provided by Memorial Sloan-Kettering Cancer Center:

Primary Outcome Measures:
  • obtain saliva or blood from non-cancer volunteers, 60 years or older to carry out anonymous genetic epidemiology studies related to resistance to cancer in elderly. [ Time Frame: conclusion of the study ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • samples perform high density genomic scans & candid gene studies carriers specif BRCA found mutat who haven't been affect by breast cancer & old than 60 find genetic cofactor may modify a predispo breast ca confer by germline mutation in BRCA1 & BRCA2. [ Time Frame: conclusion of the study ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA

Saliva or blood samples


Estimated Enrollment: 3000
Study Start Date: September 2006
Estimated Study Completion Date: December 2014
Estimated Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Intervention Details:
    Other: Saliva or Blood samples
    Extracting sample of saliva or blood only once.
Detailed Description:

This is a protocol to obtain saliva or blood samples from non-cancer affected volunteers aged 60 years or older, without a history of cancer other than non-melanoma skin cancer. These samples will be used in a genomic approach to elucidate novel pathways of cancer predisposition.

  Eligibility

Ages Eligible for Study:   60 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Nursing homes, senior centers, health fairs or other community organizations.

Criteria

Inclusion Criteria:

  • Eligible subjects must be non-cancer affected volunteers of either gender who are 60 years of age or older at the time of saliva/blood donation.
  • Subjects will self-identify religion and country of origin of grandparents.
  • Volunteers will have (by self report) no history of cancer other than nonmelanoma skin cancer. It is recognized that there may be some errors in self report, however, the literature reports a very low error rate for self reported disease reporting for cancer as assessed by interview.

Exclusion Criteria:

  • Subjects with mental impairment will be excluded from this study.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00579618

Contacts
Contact: Kenneth Offit, MD 646-888-4067

Locations
United States, New York
Memorial Sloan-Kettering Cancer Center Recruiting
New York, New York, United States, 10065
Contact: Kenneth Offit, MD    646-888-4067      
Principal Investigator: Kenneth Offit, MD         
Sponsors and Collaborators
Memorial Sloan-Kettering Cancer Center
Susan G. Komen Breast Cancer Foundation
Beth Abraham
Gurwin Jewish Nursing & Rehabilitation Center
Hebrew Home for the Aged
Jewish Home and Hospital Lifecare System
Margaret Tietz Center
Metropolitan Jewish Health System
Northern Services Group
Parker Jewish Institute
Lenox Hill Neighborhood House
JASA at Temple Emanuel of Parkchester Senior Center
Van Cortlandt Village Senior Center
Investigators
Principal Investigator: Kenneth Offit, MD, MPH Memorial Sloan-Kettering Cancer Center
  More Information

Additional Information:
No publications provided

Responsible Party: Memorial Sloan-Kettering Cancer Center
ClinicalTrials.gov Identifier: NCT00579618     History of Changes
Other Study ID Numbers: 06-102
Study First Received: December 20, 2007
Last Updated: February 5, 2014
Health Authority: United States: Institutional Review Board

Keywords provided by Memorial Sloan-Kettering Cancer Center:
non-cancer affected volunteers
aged 60 years or older

ClinicalTrials.gov processed this record on July 29, 2014