Germline Alterations of Tumor Susceptibility Genes in New York Cancer Patients
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Purpose
The basic premise of this research proposal is to determine whether there is any significant association between germline polymorphisms and cancers of colon, breast, testicular, prostate, lung, lymphoid organs, and head and neck. This is an exploratory study designed to generate hypotheses for further research.
| Condition | Intervention |
|---|---|
|
Breast Cancer Colon Cancer Prostate Cancer Lung Cancer |
Genetic: PCR/PCR/LDR Strategy |
| Study Type: | Interventional |
| Study Design: | Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Screening |
| Official Title: | Germline Alterations of Tumor Susceptibility Genes in New York Cancer Patients |
- To collect anonymized germline DNA from patients with breast, colon, testicular, prostate, lymphoid, or head and neck cancers, as well as patients with multiple primary cancers, from select New York City ethnic groups. [ Time Frame: 20 years ] [ Designated as safety issue: No ]
- To analyze DNA samples from matched non-cancer individuals of the same ethnic groups available as part of the AMDeC-sponsored New York Cancer Study. [ Time Frame: 20 years ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 2530 |
| Study Start Date: | March 2000 |
| Estimated Study Completion Date: | March 2020 |
| Estimated Primary Completion Date: | March 2020 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Active Comparator: 1
All incident second primary cancers of colon, breast, prostate cancer and lymphoid cancer diagnosed between 1999 and present will be included in the secondary design to compare second primary cancer "cases" and first primary "controls".
|
Genetic: PCR/PCR/LDR Strategy
Evaluate the extent to which polymorphisms in BRCA1, BRCA2, PTEN, T β R1, TGF β-1, DNA repair genes (including ATM and CHK2), APC, ER, PR, MCP-1, MPIF, CCR2/5 and CCR3 are correlated with cancer incidence. Candidate genes will also be selected from 1) cytokine signaling and 2) apoptosis regulatory pathways.
|
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Placebo Comparator: 2
Controls will be volunteer blood donors from the New York Blood Center as well as normal volunteers from other AMDeC sites.
|
Genetic: PCR/PCR/LDR Strategy
Evaluate the extent to which polymorphisms in BRCA1, BRCA2, PTEN, T β R1, TGF β-1, DNA repair genes (including ATM and CHK2), APC, ER, PR, MCP-1, MPIF, CCR2/5 and CCR3 are correlated with cancer incidence. Candidate genes will also be selected from 1) cytokine signaling and 2) apoptosis regulatory pathways.
|
Detailed Description:
To establish significant correlations between genetic polymorphisms and cancer, a largescale, systematic comparison of genetic alterations utilizing a case-control methodology is proposed. To date, such studies have been limited due to the large number of samples necessary for obtaining statistical significance, and the lack of rapid and accurate methods to screen for genetic polymorphisms. We propose to utilize an anonymized design to obtain DNA from residual material from routine diagnostic blood tests, to link these samples to a limited set of clinical variables, and to test for the frequency of candidate low-penetrance cancer susceptibility alleles. These data will be combined with similar data from a control group of age- and ethnically-matched volunteers for a related cohort study to be conducted separately. Polymorphisms to be screened for include those involving the genes PTEN, APC, TGF βR-I, BLM, CHK2, a p85 phosphoprotein, ATM, ER, PR, MCP-1, MPIF, CCR2/5, CCR3, and SULT1A1. Cancers to be included are breast, colon, testicular, lung, prostate, lymphoid neoplasms, and head and neck carcinomas. Genes with SNPs known to be relevant for either the development or treatment of lymphoid malignancies will also be targeted. Specifically, candidate genes will be selected from 1) cytokine signaling, 2) DNA repair, and 3) apoptosis regulatory pathways.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Patients with a histologic diagnosis of cancer of the colon, breast, testicles, lungs, prostate, head and neck, or lymphoid organs, who have donated a diagnostic blood sample as either an inpatient or outpatient at MSKCC.
- All patients who have two or more histologic diagnoses of the same primary tumor type involving the above sites.
- Patients of Ashkenazi Jewish ancestry with a histologic diagnosis of cancer of any type.
- Samples ascertained as part of protocol 98-024A(1) are also eligible for ascertainment in this study.
Exclusion Criteria:
- MSKCC patients without a histologic diagnosis of cancer of the breast, colon, testicles, lungs, prostate, or lymphoid malignancy (including all types of lymphoma) will not be eligible for the AMDeC sponsored component of the study.
Contacts and Locations| Contact: Kenneth Offit, MD | 646-888-4067 |
| United States, New York | |
| Memorial Sloan-Kettering Cancer Center | Recruiting |
| New York, New York, United States, 10065 | |
| Principal Investigator: | Kenneth Offit, MD | Memorial Sloan-Kettering Cancer Center |
More Information
Additional Information:
No publications provided
| Responsible Party: | Memorial Sloan-Kettering Cancer Center |
| ClinicalTrials.gov Identifier: | NCT00579514 History of Changes |
| Other Study ID Numbers: | 00-014 |
| Study First Received: | December 20, 2007 |
| Last Updated: | January 29, 2013 |
| Health Authority: | United States: Institutional Review Board |
Additional relevant MeSH terms:
|
Breast Neoplasms Colonic Neoplasms Disease Susceptibility Genetic Predisposition to Disease Lung Neoplasms Prostatic Neoplasms Neoplasms by Site Neoplasms Breast Diseases Skin Diseases Colorectal Neoplasms Intestinal Neoplasms Gastrointestinal Neoplasms Digestive System Neoplasms |
Digestive System Diseases Gastrointestinal Diseases Colonic Diseases Intestinal Diseases Disease Attributes Pathologic Processes Respiratory Tract Neoplasms Thoracic Neoplasms Lung Diseases Respiratory Tract Diseases Genital Neoplasms, Male Urogenital Neoplasms Genital Diseases, Male Prostatic Diseases |
ClinicalTrials.gov processed this record on May 19, 2013