Effectiveness of Intensive Cognitive Behavioral Therapy in Treating Adolescent Panic Disorder and Agoraphobia

• Anxiety Disorders Interview Schedule-Child and Parent Versions: Clinical Severity Rating, Agoraphobia Ratings, Panic Attack Frequency Scores, and Internal Sensation Anxiety Ratings [ Time Frame: Measured at Months 3, 6, and 12 post-treatment ] [ Designated as safety issue: No ]
  
• Panic Disorder Severity Scale-Child Version [ Time Frame: Measured at Months 3, 6, and 12 post-treatment ] [ Designated as safety issue: No ]
  

• Multidimensional Anxiety Scale for Children [ Time Frame: Measured at Months 3, 6, and 12 post-treatment ] [ Designated as safety issue: No ]
  
• Childhood Anxiety Sensitivity Index [ Time Frame: Measured at Months 3, 6, and 12 post-treatment ] [ Designated as safety issue: No ]
  
• Fear and Avoidance Hierarchy [ Time Frame: Measured at Months 3, 6, and 12 post-treatment ] [ Designated as safety issue: No ]
  
• Children's Depression Inventory [ Time Frame: Measured at Months 3, 6, and 12 post-treatment ] [ Designated as safety issue: No ]
  
• The Panic Attack Record [ Time Frame: Measured at Months 3, 6, and 12 post-treatment ] [ Designated as safety issue: No ]
  
• Subjective Symptoms Scale [ Time Frame: Measured at Months 3, 6, and 12 post-treatment ] [ Designated as safety issue: No ]
  
• Panic and Phobia Questionnaire [ Time Frame: Measured at Months 3, 6, and 12 post-treatment ] [ Designated as safety issue: No ]
  
• Participant Global Impression of Improvement (PGI) [ Time Frame: Measured at Months 3, 6, and 12 post-treatment ] [ Designated as safety issue: No ]
  
• Perceptions of Treatment Questionnaire: Adolescent and Parent Versions [ Time Frame: Measured at Months 3, 6, and 12 post-treatment ] [ Designated as safety issue: No ]
  
• Children's Perception Scale (Locus of Control Scale) [ Time Frame: Measured at Months 3, 6, and 12 post-treatment ] [ Designated as safety issue: No ]
  
• Child Behavior Checklist (CBCL) [ Time Frame: Measured at Months 3, 6, and 12 post-treatment ] [ Designated as safety issue: No ]
  
• Stress Index for Parents of Adolescents [ Time Frame: Measured at Months 3, 6, and 12 post-treatment ] [ Designated as safety issue: No ]
  
• Parenting Locus of Control Scale [ Time Frame: Measured at Months 3, 6, and 12 post-treatment ] [ Designated as safety issue: No ]
  
• Therapy Attitude Inventory [ Time Frame: Measured at Months 3, 6, and 12 post-treatment ] [ Designated as safety issue: No ]
  
• Family Assessment Measure (FAM) [ Time Frame: Measured at Months 3, 6, and 12 post-treatment ] [ Designated as safety issue: No ]
  
• Depression Anxiety and Stress Scale (DASS) [ Time Frame: Measured at Months 3, 6, and 12 post-treatment ] [ Designated as safety issue: No ]
  

Panic disorder (PD) in adolescents is a prevalent and chronic anxiety disorder. People with PD experience unexpected attacks of fear, along with elevated heart rate, dizziness, faintness, weakness, and increased sweating. During these panic attacks, people may feel numbness in their hands, flushed or chilled, nauseous, or pain in the chest, and they may lose touch with reality. PD can lead to substantial social impairment for adolescents, including avoidance of school, independent activities, and peer involvement. When PD progresses so far that a person avoids public places where a panic attack might occur, the person is said to have a condition known as agoraphobia. Weekly sessions of cognitive behavioral therapy (CBT) appear to be effective in treating panic disorder with agoraphobia (PDA). However, many adolescents with PDA and their families report the need for a more immediate relief from the disorder. This study will evaluate the effectiveness of intensive CBT in treating adolescents with PDA.

Participants in this single blind study will be randomly assigned to one of three conditions: intensive CBT treatment including family members, intensive CBT treatment without family members, or a waitlist control group. All participants in the intensive CBT treatment groups will undergo 8 days of intensive CBT, for a total of 6 sessions. On Days 1 through 3 of treatment, participants will attend daily, 2-hour CBT sessions. The CBT sessions will include psychoeducation about anxiety, tactics to restructure anxiety-provoking thoughts, and exposure to bodily sensations that trigger panic. On Days 4 and 5, participants will meet with a therapist to learn ways to approach previously feared situations. On Days 6 and 7, participants will continue working independently or with family members to solidify skills. On Day 8, participants will attend a final 2-hour session to consolidate skills, review the independent weekend activities, and discuss ways to apply skills to the home environment. Parents of participants in the parental involvement group will attend the last 30 minutes of sessions, complete homework assignments, learn ways to coach their children through episodes, and participate in selected exposures. After 6 weeks of waitlist, participants in the waitlist control group will receive active treatment following the same procedures as the initial active treatment. All participants will be assessed at Months 3, 6, and 12 post-treatment.