Microarray Analysis of Gene Expression and Identification of Progenitor Cells in Lung Carcinoma

The recruitment status of this study is unknown because the information has not been verified recently.

Verified July 2010 by Stanford University.
Recruitment status was Recruiting

Sponsor:

Collaborator:

TRDRP

Information provided by:

Stanford University

ClinicalTrials.gov Identifier:

NCT00568906

First received: December 4, 2007

Last updated: July 2, 2010

Last verified: July 2010

History of Changes

Purpose

This study will investigate gene expression profiles in normal human lung tissue, lung carcinoma and metastatic tumor to the lung. The expression of up to 20,000 genes in a given lung tissue sample will be examined by cDNA microarray analysis and compared to normal lung tissue. In addition, we hope to identify a particular subset of lung cancer cells with an enhanced capacity for proliferation and self-renewal , analogous to the stem cells recently identified for certain types of leukemia, breast cancer and brain tumors.

Condition
Carcinoma, Giant Cell Carcinoma, Non-Small-Cell Lung Lung Cancer

Study Type:	Observational
Study Design:	Observational Model: Case Control Time Perspective: Prospective
Official Title:	Microarray Analysis of Gene Expression and Identification of Progenitor Cells in Lung Carcinoma

Resource links provided by NLM:

MedlinePlus related topics: Cancer Lung Cancer

U.S. FDA Resources

Further study details as provided by Stanford University:

Biospecimen Retention: Samples With DNA

Lung tissue or pleural fluid.

Estimated Enrollment:	150
Study Start Date:	February 2002
Estimated Study Completion Date:	June 2011
Estimated Primary Completion Date:	November 2010 (Final data collection date for primary outcome measure)

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

Patients who agree to participate in this study will be those who are undergoing wedge resection, lobectomy on pneumonectomy for clinically diagnosed lung carcinoma or metastatic tumors to the lung, or who are undergoing therapeutic or diagnostic thoracentesis for malignant pleural effusion.

Criteria

Inclusion Criteria:Adults with non small cell lung cancer

Exclusion Criteria:NA

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00568906

Contacts

Contact: Susan Jacobs, RN

(650) 725-8082

ssjpulm@stanford.edu

Locations

United States, California
Stanford University School of Medicine	Recruiting
Stanford, California, United States, 94305
Contact: Susan Jacobs, RN 650-725-8082 ssjpulm@stanford.edu
Contact: Cancer Clinical Trials Office (650) 498-7061
Principal Investigator: Glenn D. Rosen
Sub-Investigator: Laurie Elizabeth Ailles
Sub-Investigator: Walter B Cannon
Sub-Investigator: Dr Jessica S. Donington
Sub-Investigator: Cathy Shachaf
Sub-Investigator: Heather A. Wakelee
Sub-Investigator: Irving L. Weissman M.D.
Sub-Investigator: Richard I Whyte
Sub-Investigator: Tze-Ming Chen
Principal Investigator: Daya Upadhyay

Sponsors and Collaborators

Stanford University

TRDRP

Investigators

Principal Investigator:	Daya Upadhyay	Stanford University
Principal Investigator:	Glenn D. Rosen	Stanford University

More Information

No publications provided

Responsible Party:	Glenn D. Rosen, Stanford University School of Medicine
ClinicalTrials.gov Identifier:	NCT00568906 History of Changes
Other Study ID Numbers:	SU-11062007-807, 76094, LUN0011
Study First Received:	December 4, 2007
Last Updated:	July 2, 2010
Health Authority:	United States: Institutional Review Board

Additional relevant MeSH terms:

Carcinoma
Carcinoma, Non-Small-Cell Lung
Carcinoma, Giant Cell
Carcinoma, Bronchogenic
Lung Neoplasms
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type

Neoplasms
Bronchial Neoplasms
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Lung Diseases
Respiratory Tract Diseases

ClinicalTrials.gov processed this record on May 22, 2013

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