Immunohistochemical & Immunoblot Analysis of NIS (Na+/I-Symporter) in Archival & Frozen Tissue Sample
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Purpose
The goal of this study is to study NIS expression in benign and malignant breast and thyroid samples using archival formalin-fixed paraffin-embedded tissue sections.
| Condition |
|---|
|
Breast Cancer Stomach Neoplasms Salivary Gland Neoplasms Thyroid Cancer |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Retrospective |
| Official Title: | Immunohistochemical & Immunoblot Analysis of NIS (Na+/I-Symporter) in Archival and Frozen Human Tissue Samples |
Cases will be identified from clinic patient medical records and linked to pathology reports. The surgical pathology record number will thus be obtained and used to retrieve the archival blocks and slides. Approximately three representative blocks will be selected and 4-6 four micron thick sections will be cut on a microtome. Cases with limited archived diagnostic material will not be selected nor blocks where there is little materials.
| Estimated Enrollment: | 300 |
| Study Start Date: | October 2000 |
| Estimated Study Completion Date: | December 2016 |
| Estimated Primary Completion Date: | December 2016 (Final data collection date for primary outcome measure) |
The objective of the study is to further understanding of proteins that occur in both normal cells and tumor cells and to learn more about certain diseases and potential alternative treatments for these diseases.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Cases will be identified from clinic patient medical records and linked to pathology reports. The surgical pathology record number will thus be obtained and used to retrieve the archival blocks and slides. In addition, all these participants will be clinical patients of the Protocol Director, thus the Physician will always be familiar with the participants.
Inclusion Criteria:
- Patient must be over the age of 18.
- Patients must have benign and malignant breast and thyroid cancer.
- Patient mus sign consent form.
Exclusion Criteria:
1. No children will be allowed.
Contacts and Locations| United States, California | |
| Stanford University School of Medicine | Recruiting |
| Stanford, California, United States, 94305 | |
| Contact: Marilyn Florero 650-724-1953 florerom@stanford.edu | |
| Contact: Cancer Clinical Trials Office (650) 498-7061 | |
| Principal Investigator: Irene L. Wapnir | |
| Sub-Investigator: Ralph S. Greco MD | |
| Sub-Investigator: Kent W Nowels | |
| Principal Investigator: | Irene L. Wapnir | Stanford University |
More Information
No publications provided
| Responsible Party: | Stanford University |
| ClinicalTrials.gov Identifier: | NCT00568438 History of Changes |
| Other Study ID Numbers: | BRSNSTU0011, 75622, 11005 |
| Study First Received: | December 4, 2007 |
| Last Updated: | November 5, 2012 |
| Health Authority: | United States: Food and Drug Administration United States: Institutional Review Board |
Additional relevant MeSH terms:
|
Salivary Gland Neoplasms Breast Neoplasms Neoplasms Thyroid Neoplasms Stomach Neoplasms Neoplasms by Site Breast Diseases Skin Diseases Endocrine Gland Neoplasms Head and Neck Neoplasms Endocrine System Diseases |
Thyroid Diseases Gastrointestinal Neoplasms Digestive System Neoplasms Digestive System Diseases Gastrointestinal Diseases Stomach Diseases Mouth Neoplasms Mouth Diseases Stomatognathic Diseases Salivary Gland Diseases |
ClinicalTrials.gov processed this record on May 23, 2013