Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome
This study is currently recruiting participants.
Verified September 2011 by Washington University School of Medicine
Sponsor:
Washington University School of Medicine
Information provided by (Responsible Party):
Washington University School of Medicine
ClinicalTrials.gov Identifier:
NCT00565903
First received: November 29, 2007
Last updated: September 22, 2011
Last verified: September 2011
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Purpose
Pleuropulmonary Blastoma (PPB) is a rare lung tumor which develops in childhood. The underlying genetic factors which contribute to the development and progression of PPB is not defined. We are working to identify the genetic factors which may contribute to the development of this rare tumor.
| Condition |
|---|
|
Pleuropulmonary Blastoma Cystic Nephroma |
| Study Type: | Observational |
| Study Design: | Observational Model: Family-Based Time Perspective: Prospective |
| Official Title: | Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome |
Resource links provided by NLM:
Genetics Home Reference related topics:
DICER1 syndrome
MedlinePlus related topics:
Cancer
U.S. FDA Resources
Further study details as provided by Washington University School of Medicine:
Primary Outcome Measures:
- Identify the genetic factors which contribute to the development or progression of pleuropulmonary blastoma [ Time Frame: 10 years ] [ Designated as safety issue: No ]
Secondary Outcome Measures:
- Define the clinical features of the pleuropulmonary blastoma (PPB) familial cancer syndrome. [ Time Frame: 10 years ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
We are collecting blood samples or saliva samples. When available, we also collect tumor samples from prior surgical procedures.
| Estimated Enrollment: | 2000 |
| Study Start Date: | March 2005 |
| Estimated Study Completion Date: | March 2015 |
Eligibility| Ages Eligible for Study: | up to 95 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Study Population
Families who have a child or adult with pleuropulmonary blastoma or cystic nephroma are invited to participate.
Criteria
Inclusion Criteria:
- child or adult diagnosed with pleuropulmonary blastoma or cystic nephroma.
Exclusion Criteria:
- child or adult who does not have a confirmed diagnosis of pleuropulmonary blastoma or cystic nephroma.
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00565903
Contacts
| Contact: Paul Goodfellow, Ph.D. | 314-362-2032 | goodfellowp@wudosis.wustl.edu |
| Contact: Jennifer L. Ivanovich, MS, MBA | 314-454-5076 | jen@ccadmin.wustl.edu |
Locations
| United States, Missouri | |
| Washington University School of Medicine | Recruiting |
| St. Louis, Missouri, United States, 63110 | |
| Contact: Paul Goodfellow, PhD 314-362-2032 goodfellowp@wudosis.wustl.edu | |
| Contact: Jennifer Ivanovich, MS, MBA 314-454-5076 jen@ccadmin.wustl.edu | |
| Principal Investigator: Paul Goodfellow, PhD | |
| Sub-Investigator: Jennifer Ivanovich, MS, MBA | |
| Sub-Investigator: Ashley Hill, MD | |
Sponsors and Collaborators
Washington University School of Medicine
Investigators
| Principal Investigator: | Paul Goodfellow, PhD | Washington University School of Medicine |
| Study Director: | Jennifer Ivanovich, MS, MBA | Washington University School of Medicine |
| Study Chair: | Ashley Hill, MD | Children's Research Institute |
| Study Chair: | Jack Priest, MD | Children's Hospital and Clinics of Minnesota |
More Information
Additional Information:
No publications provided
| Responsible Party: | Washington University School of Medicine |
| ClinicalTrials.gov Identifier: | NCT00565903 History of Changes |
| Other Study ID Numbers: | 05-0192 / 201012830 |
| Study First Received: | November 29, 2007 |
| Last Updated: | September 22, 2011 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by Washington University School of Medicine:
|
pleuropulmonary blastoma PPB cystic nephroma |
Additional relevant MeSH terms:
|
Pulmonary Blastoma Neoplasms, Complex and Mixed Neoplasms by Histologic Type Neoplasms |
Lung Neoplasms Respiratory Tract Neoplasms Thoracic Neoplasms Neoplasms by Site |
ClinicalTrials.gov processed this record on June 13, 2013