A Study of SB751689 in Japanese Postmenopausal Women

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
GlaxoSmithKline
ClinicalTrials.gov Identifier:
NCT00554255
First received: November 2, 2007
Last updated: April 11, 2013
Last verified: April 2012
  Purpose

To investigate the safety and tolerability, PK and PD of SB751689 following single and 5-day multiple oral doses of 100, 200, and 400 mg in Japanese postmenopausal subjects.


Condition Intervention Phase
Osteoporosis
Drug: SB751689
Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety Study
Intervention Model: Crossover Assignment
Masking: Single Blind (Subject)
Primary Purpose: Treatment
Official Title: Phase I Study of SB751689 - Single and Multiple Oral Dose Study in Japanese Postmenopausal Women -

Resource links provided by NLM:


Further study details as provided by GlaxoSmithKline:

Primary Outcome Measures:
  • Adverse events, change in clinical laboratory tests, vital signs, 12lead ECG [ Time Frame: throughout the study ]

Secondary Outcome Measures:
  • Pharmacokinetics and Pharmacodynamics of SB751689 [ Time Frame: throughout the study ]

Estimated Enrollment: 18
Study Start Date: October 2006
Intervention Details:
    Drug: SB751689
    Other Name: SB751689
  Eligibility

Ages Eligible for Study:   50 Years to 70 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • The subject is considered as healthy by the investigator at screening.
  • Healthy subjects are defined as individuals who are free from clinically significant illness or disease as determined by their medical history, physical examination, laboratory studies, and other tests
  • Japanese healthy postmenopausal woman as defined as being amenorrheic for at least 1 year at screening with <157.79mIU/mL of FSH levels.
  • Body weight >= 45 kg and BMI within the range 18.5 -25.0 kg/m2.
  • The subject is within the following criteria as screening;Liver function tests (ALT, AST, GGT, alkaline phosphatase, total bilirubin), CPK, serum parathyroid hormone (iPTH) test, vitamin D (1,25(OH2 D3)) levels, Serum calcium
  • Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form.
  • Non-smokers (at least 6 months)
  • The subject is able to attend all visits and complete the study.

Exclusion Criteria:

  • The subject has any clinically relevant abnormality on medical examination, vital sign, clinical laboratory test or medical history at screening in the medical opinion of the investigator or the subject has a medical history that is not considered as eligible for inclusion in this study by the investigator.
  • History of sensitivity to any of the study medications or components thereof (except pollenosis without any signs or symptoms).
  • Participation in a clinical study or post-marketing study with an investigational or a non-investigational product or device within 4 months of preceding the first dose of study medication.
  • Participation in another clinical study or post-marketing study in which the subject is or will be exposed to an investigational or a non-investigational product or device.
  • Positive for syphilis, HIV antibody, hepatitis B antigen or hepatitis C antibody, HTLV-1 antibody at screening.
  • Positive urine drug screen at screening.
  • Donation of blood in excess of 400 mL within the previous 4 months or 200mL within the previous 1 month of screening.
  • Use of prescription or non-prescription drugs, herbal and dietary supplements, within 14 days prior to the first dose of study medication.
  • History of drug abuse or current conditions of drug abuse or alcoholism.
  • History of regular alcohol consumption exceeding 7 units/week (>350mL of beer/unit) within 6 months of screening.
  • Subjects with a history of renal, hepatic, or biliary disease.
  • History of clinically significant cardiovascular disease.
  • History of pernicious anemia, pancreatitis, osteosarcoma or kidney stones.
  • Subjects who have had history of significant gastrointestinal disease (e.g., gastrointestinal malabsorptive disease, colostomy, chronic gastroesophageal reflux disease, Crohn's disease, ulcerative colitis, gastric or duodenal ulcer, gastrointestinal tract bleeding, short bowel syndrome, sprue, lactose intolerance, irritable bowel syndrome).
  • Subjects with any history of a gastrointestinal surgical procedure that might affect the absorption of SB-751689 (e.g. cholecystectomy, gastrointestinal bypass surgery, partial or total gastrectomy, small bowel resection).
  • Medical conditions which might alter bone metabolism, including hyperparathyroidism, hypoparathyroidism, hyperthyroidism, hypothyroidism, Paget's disease, malabsorption, or Cushing's syndrome, and hypogonadism, hypocalcemia, hypercalcemia, hypophosphatemia, hypomagnesemia, hypermagnesemia, osteopetrosis, osteomalacia, and recent (within one year) history of fracture or prolonged bedrest.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00554255

Sponsors and Collaborators
GlaxoSmithKline
Investigators
Study Director: GSK Clinical Trials GlaxoSmithKline
  More Information

No publications provided

Responsible Party: GlaxoSmithKline
ClinicalTrials.gov Identifier: NCT00554255     History of Changes
Other Study ID Numbers: 108543
Study First Received: November 2, 2007
Last Updated: April 11, 2013
Health Authority: Japan: Ministry of Health, Labor and Welfare

Keywords provided by GlaxoSmithKline:
Pharmacodynamics
Japanese
safety
Pharmacokinetics

Additional relevant MeSH terms:
Osteoporosis
Bone Diseases, Metabolic
Bone Diseases
Musculoskeletal Diseases

ClinicalTrials.gov processed this record on October 16, 2014