Does Aldosterone Cause Hypertension by a Non-Renal Mechanism?
Recruitment status was Not yet recruiting
It is well known that Aldosterone (aldo) can cause hypertension (HBP). Since aldo is known to cause the kidney to retain sodium (Na) and Na retention is known to cause HBP, it has been thought that the mechanism by which aldo causes HBP is by Na retention. Recent studies have suggested that aldo has many effects in addition to its ability to cause the kidney to retain Na. To test the hypothesis that aldo can cause HBP in a manner which does not involve Na retention, we plan, in this protocol, to give Eplerenone, a specific aldo antagonist, to patients on dialysis who have HBP. A positive effect of Eplerenone to lower HBP in these patients would support this hypothesis.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Caregiver, Investigator)
Primary Purpose: Diagnostic
|Official Title:||Does Aldosterone Cause Hypertension by a Non-Renal Mechanism?|
- Significant drop in blood pressure with Eplerenone when compared to placebo. [ Time Frame: days ]
|Study Start Date:||November 2007|
|Estimated Study Completion Date:||November 2009|
Administer Eplerenone, 25 mg, orally twice daily for 4 weeks.
Administer Eplerenone, 25 mg,orally twice daily for 4 weeks.
Placebo Comparator: placebo
Administer a placebo tablet orally twice daily for 4 weeks
Administer a placebo tablet orally twice daily for 4 weeks.
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|Contact: Linda Shavit, MD||02 email@example.com|
|Contact: Itzchak Slotki, MD||o2 firstname.lastname@example.org|
|Shaare Zedek Medical Center||Not yet recruiting|
|Jerusalem, Israel, 91031|
|Contact: Linda Shavit, MD 02 6555086 email@example.com|
|Principal Investigator: Linda Shavit, MD|
|Principal Investigator:||Linda Shavit, MD||Shaare Zedek Medical Center|