Physiological Effects of Androstadienone Exposure
The reason for doing this research is to understand why different people show different responses when they smell an odor called androstadienone. Androstadienone is a chemical found in male sweat. Other studies have shown that smelling this chemical can cause people to experience sweating, changes in skin temperature, and changes in a stress hormone call cortisol. These responses, which are called "physiological effects," are stronger in some people than in others.
We are interested in finding out whether these individual differences are genetic, that is caused by differences in our genes. Humans have about 1000 genes for odorant receptors. These are the molecules that bind and detect odor molecules in our nose and allow us to respond to so many different odors. It has been shown that some of these genes exist in two forms: a functional one and one that has been mutated and is therefore no longer functional.
We think that people who do not respond to a specific odor may carry the non-functional form of the gene for the receptor that detects the odor molecule. To test this idea we want to find people who respond strongly to a specific smell, and compare their odorant receptor genes with those of people who respond weakly to the odor.
|Study Design:||Time Perspective: Prospective|
|Official Title:||Physiological Effects of Androstadienone Exposure|
- Skin temperature, skin conductance and salivary cortisol level. [ Time Frame: Monthly over approximately a 5 month period/volunteer ] [ Designated as safety issue: No ]
- The ability to detect odor. [ Time Frame: Monthly over a 5 month period. ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
|Study Start Date:||December 2007|
|Study Completion Date:||July 2010|
|Primary Completion Date:||July 2010 (Final data collection date for primary outcome measure)|
The study consists of five visits. The first visit is a screening visit at which the eligibility of the subject is determined and a blood sample is taken. At this visit, the subject is also given ovulation test strips and instructions to perform urine-based ovulation self-tests at home for a period of several days following the onset of menstruation. The subject is instructed to test her urine at home until an LH surge is detected.
When the subject ovulates and is available for a visit she will come to the Rockefeller University Hospital within one day of detecting an LH surge for the first of four Test Sessions.
The four Test Sessions are identical with the exception that the subject is exposed to a different odor stimulus.
We will be measuring:
- skin temperature
- sweating, as measured by skin conductance
- salivary cortisol levels.
|United States, New York|
|The Rockefeller University Hospital|
|New York, New York, United States, 10065|
|Principal Investigator:||Leslie Vosshall, Ph.D.||The Rockefeller University|