Analyzing Genes That May Increase the Risk of Developing High Blood Pressure

This study has been completed.
Sponsor:
Collaborator:
Information provided by:
Case Western Reserve University
ClinicalTrials.gov Identifier:
NCT00549991
First received: October 24, 2007
Last updated: November 26, 2013
Last verified: April 2009
  Purpose

High blood pressure is one of the most common health problems in the United States. Genetic variations may cause some people to be more susceptible to developing high blood pressure. This study will identify variations in genes known to play a part in the development of high blood pressure.


Condition
Hypertension

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Fine Mapping of Hypertension Genes Detected by Admixture Mapping in the FBPP

Resource links provided by NLM:


Further study details as provided by Case Western Reserve University:

Primary Outcome Measures:
  • Genetic variations [ Time Frame: Measured through admixture mapping genetic analysis ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA

Whole blood


Enrollment: 8687
Study Start Date: August 2007
Study Completion Date: June 2012
Detailed Description:

High blood pressure affects nearly one third of all individuals in the United States. It is especially common in African Americans, with more than 40% of African Americans diagnosed with this condition. High blood pressure usually develops earlier in life and is more severe in African Americans than in other racial or ethnic groups. Many factors can cause high blood pressure, including stress, diet, diabetes, kidney disease, or obesity. Previous studies have also shown that genetic variations on two regions of chromosomes 6 and 21 may predispose some people to develop high blood pressure. Admixture mapping is a type of genetic analysis that aims to identify disease-causing genetic variations across different populations of people. Using admixture mapping, this study will examine previously collected genetic samples from African American participants in the Family Blood Pressure Program (FBPP) study and from African American, Mexican American, Nigerian, and Jamaican participants enrolled in other clinical studies. Study researchers will analyze the samples to identify and characterize genetic variations that are associated with an increased risk of high blood pressure in the African American population, as well as other racial and ethnic groups.

  Eligibility

Ages Eligible for Study:   21 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Previously collected genetic samples from African American participants in the Family Blood Pressure Program (FBPP) study and from African American, Mexican American, Nigerian, and Jamaican participants enrolled in other clinical studies will be examined.

Criteria

Inclusion Criteria:

  • Participated in the FBPP study (African American [800 people with high blood pressure and 800 control group participants] and Mexican American participants)
  • Participated in the American Family Study (African American participants)
  • Participated in the Phenotyping Study (African American, Nigerian, and Jamaican participants)
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00549991

Locations
United States, Ohio
Case Western Reserve University
Cleveland, Ohio, United States, 44106
Sponsors and Collaborators
Case Western Reserve University
Investigators
Principal Investigator: Xiaofeng Zhu, PhD Case Western Reserve University
  More Information

No publications provided

Responsible Party: Xiaofeng Zhu, PhD, Case Western Reserve University
ClinicalTrials.gov Identifier: NCT00549991     History of Changes
Other Study ID Numbers: 1415, R01HL086718
Study First Received: October 24, 2007
Last Updated: November 26, 2013
Health Authority: United States: Federal Government

Keywords provided by Case Western Reserve University:
High Blood Pressure

Additional relevant MeSH terms:
Hypertension
Vascular Diseases
Cardiovascular Diseases

ClinicalTrials.gov processed this record on April 14, 2014